MAPKAPK5 Antibody (PACO05575)
- SKU:
- PACO05575
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | MAPKAPK5 Antibody (PACO05575) |
抗体コード: | PACO05575 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:10000, WB:1:500-1:2000 |
反応性: | Human, Mouse |
免疫原: | Synthesized peptide derived from human PRAK around the non-phosphorylation site of T182. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | MAPKAPK5; PRAK; MAP kinase-activated protein kinase 5; MAPK-activated protein kinase 5; MAPKAP kinase 5; MAPKAP-K5; MAPKAPK-5; MK-5; MK5; p38-regulated/activated protein kinase; PRAK |
UniProt Protein Function: | MAPKAPK5: a member of the MAPKAPK family of protein kinases. Activated through phosphorylation by MAP kinases including ERK, p38-alpha, and MAPp38-beta In response to cellular stress and proinflammatory cytokines. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. |
UniProt Protein Details: | Protein type:EC 2.7.11.1; Tumor suppressor; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; CAMK group; MAPKAPK family; MAPKAPK subfamily Chromosomal Location of Human Ortholog: 12q24.13 Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus Molecular Function:calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity; MAP kinase kinase activity; p53 binding; protein binding; protein serine/threonine kinase activity Biological Process: negative regulation of TOR signaling pathway; peptidyl-serine phosphorylation; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; protein amino acid autophosphorylation; Ras protein signal transduction; regulation of translation; signal transduction |
NCBI Summary: | The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012] |
UniProt Code: | Q8IW41 |
NCBI GenInfo Identifier: | 52000829 |
NCBI Gene ID: | 8550 |
NCBI Accession: | Q8IW41.2 |
UniProt Secondary Accession: | Q8IW41,O60491, Q86X46, Q9BVX9, Q9UG86, B3KVA5, |
UniProt Related Accession: | Q8IW41 |
Molecular Weight: | 54,035 Da |
NCBI Full Name: | MAP kinase-activated protein kinase 5 |
NCBI Synonym Full Names: | mitogen-activated protein kinase-activated protein kinase 5 |
NCBI Official Symbol: | MAPKAPK5 |
NCBI Official Synonym Symbols: | MK5; MK-5; PRAK; MAPKAP-K5 |
NCBI Protein Information: | MAP kinase-activated protein kinase 5 |
UniProt Protein Name: | MAP kinase-activated protein kinase 5 |
UniProt Synonym Protein Names: | p38-regulated/activated protein kinase; PRAK |
Protein Family: | MAP kinase-activated protein kinase |
UniProt Gene Name: | MAPKAPK5 |
UniProt Entry Name: | MAPK5_HUMAN |