UniProt Protein Function: | Nik: a protein kinase of the STE group of kinases. Binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. |
UniProt Protein Details: | Protein type:EC 2.7.11.25; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE-Unique family Chromosomal Location of Human Ortholog: 17q21.31 Cellular Component: cytoplasm; cytosol; fibrillar center; intracellular membrane-bound organelle; nucleus Molecular Function:kinase activity; NF-kappaB-inducing kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity Biological Process: actin cytoskeleton organization and biogenesis; I-kappaB kinase/NF-kappaB cascade; immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; T cell costimulation; tumor necrosis factor-mediated signaling pathway |
NCBI Summary: | This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q99558 |
NCBI GenInfo Identifier: | 92090612 |
NCBI Gene ID: | 9020 |
NCBI Accession: | Q99558.2 |
UniProt Secondary Accession: | Q99558,Q8IYN1, A8K2D8, D3DX67, |
UniProt Related Accession: | Q99558 |
Molecular Weight: | 104kDa |
NCBI Full Name: | Mitogen-activated protein kinase kinase kinase 14 |
NCBI Synonym Full Names: | mitogen-activated protein kinase kinase kinase 14 |
NCBI Official Symbol: | MAP3K14 |
NCBI Official Synonym Symbols: | HS; NIK; HSNIK; FTDCR1B |
NCBI Protein Information: | mitogen-activated protein kinase kinase kinase 14 |
UniProt Protein Name: | Mitogen-activated protein kinase kinase kinase 14 |
UniProt Synonym Protein Names: | NF-kappa-beta-inducing kinase; HsNIK; Serine/threonine-protein kinase NIK |
Protein Family: | Mitogen-activated protein kinase kinase kinase |
UniProt Gene Name: | MAP3K14 |