UniProt Protein Function: | LZK: a TKL kinase of the MLK family. Synergizes with antioxidant protein-1 to activate NF-kappaB. Forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway. This kinase can phosphorylate and activate JNK and MKK7. Contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. |
UniProt Protein Details: | Protein type:EC 2.7.11.25; Kinase, protein; LZK subfamily; MLK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group Chromosomal Location of Human Ortholog: 3q27.2 Cellular Component: IkappaB kinase complex; membrane Molecular Function:identical protein binding; MAP kinase kinase kinase activity; protein binding; protein homodimerization activity; protein kinase binding; protein serine/threonine kinase activity Biological Process: activation of MAPKK activity; activation of NF-kappaB transcription factor; JNK cascade; protein amino acid autophosphorylation; protein amino acid phosphorylation |
NCBI Summary: | The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008] |
UniProt Code: | O43283 |
NCBI GenInfo Identifier: | 68052263 |
NCBI Gene ID: | 9175 |
NCBI Accession: | O43283.1 |
UniProt Secondary Accession: | O43283,Q05BY6, Q15450, Q2NKN3, B2R6U2, B4DLE3, B4DMV2 B4DZJ4, D3DNU1, |
UniProt Related Accession: | O43283 |
Molecular Weight: | 108kDa |
NCBI Full Name: | Mitogen-activated protein kinase kinase kinase 13 |
NCBI Synonym Full Names: | mitogen-activated protein kinase kinase kinase 13 |
NCBI Official Symbol: | MAP3K13 |
NCBI Official Synonym Symbols: | LZK; MLK; MEKK13 |
NCBI Protein Information: | mitogen-activated protein kinase kinase kinase 13 |
UniProt Protein Name: | Mitogen-activated protein kinase kinase kinase 13 |
UniProt Synonym Protein Names: | Leucine zipper-bearing kinase; Mixed lineage kinase; MLK |
Protein Family: | Mitogen-activated protein kinase kinase kinase |
UniProt Gene Name: | MAP3K13 |