UniProt Protein Function: | MEKK1: a protein kinase of the STE11 family. Phosphorylates and activates MKK4 and -7, which in turn activate JNK1, -2 and -3. Contains 1 RING-type zinc finger. The RING finger domain of MEKK1 exhibits E3 ubiquitin ligase activity toward c-Jun. c-Jun is downregulated in response to osmotic stress via ubiquitination-mediated degradation by the RING finger domain of MEKK1. Overexpressed/overactivated in multiple tumor types. The Mek1/2 inhibitor U0126 blocks export of influenza viral particles and has been suggested as an antiviral treatment. Single mutations at the same point of each gene also associated with cardiofaciocutaneous syndrome, (also linked with Braf and Kras mutations), displaying morphological, cardiac and mental defects. Inhibitors: U0126, CI-1040/PD184352, PD-0325901 (Phase I cancer), ARRY-142886 (Phase 1, cancer).Protein type: Kinase, protein; EC 2.7.11.25; Protein kinase, STE; Ubiquitin conjugating system; Protein kinase, Ser/Thr (non-receptor); Ubiquitin ligase; Ligase; STE group; STE11 familyCellular Component: cell junction; cytoplasm; cytoskeleton; filamentous actin; membraneMolecular Function: cytoskeletal protein binding; JUN kinase binding; JUN kinase kinase kinase activity; MAP kinase kinase kinase activity; mitogen-activated protein kinase binding; mitogen-activated protein kinase kinase binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; sphingolipid binding; ubiquitin-protein ligase activityBiological Process: activation of JNK activity; apoptotic mitochondrial changes; camera-type eye development; JNK cascade; morphogenesis of an epithelial sheet; positive regulation of actin filament polymerization; regulation of cell migration; transforming growth factor beta receptor signaling pathway; wound healing |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | P53349 |
NCBI GenInfo Identifier: | 19860665 |
NCBI Gene ID: | 26401 |
NCBI Accession: | P53349.3 |
UniProt Secondary Accession: | P53349,Q60831, Q9R0U3, Q9R256 |
UniProt Related Accession: | P53349 |
Molecular Weight: | 161,289 Da |
NCBI Full Name: | Mitogen-activated protein kinase kinase kinase 1 |
NCBI Synonym Full Names: | mitogen-activated protein kinase kinase kinase 1 |
NCBI Official Symbol: | Map3k1 |
NCBI Official Synonym Symbols: | Mekk; MEKK1; MAPKKK1 |
NCBI Protein Information: | mitogen-activated protein kinase kinase kinase 1 |
UniProt Protein Name: | Mitogen-activated protein kinase kinase kinase 1 |
UniProt Synonym Protein Names: | MAPK/ERK kinase kinase 1; MEK kinase 1; MEKK 1 |
Protein Family: | MAP3K12-binding inhibitory protein |
UniProt Gene Name: | Map3k1 |
UniProt Entry Name: | M3K1_MOUSE |