MAP2K5 Antibody, Biotin conjugated (PACO50517)
- SKU:
- PACO50517
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Description
抗体名: | MAP2K5 Antibody, Biotin conjugated (PACO50517) |
抗体コード: | PACO50517 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Dual specificity mitogen-activated protein kinase kinase 5 protein (1-190AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. |
シノニム: | Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5), MAP2K5, MEK5 MKK5 PRKMK5 |
UniProt Protein Function: | MEK5: a dual specificity protein kinase of the STE7 family. Activates ERK5 and is itself phosphorylated and activated by MEKK3, as well as by atypical protein kinase C isoforms. Involved in growth factor stimulated cell proliferation and muscle cell differentiation. Four alternatively spliced isoforms have been described. |
UniProt Protein Details: | Protein type:Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); Kinase, protein; EC 2.7.12.2; STE group; STE7 family Chromosomal Location of Human Ortholog: 15q23 Cellular Component: cytoplasm; nucleus; spindle Molecular Function:ATP binding; metal ion binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; protein-tyrosine kinase activity Biological Process: activation of MAPK activity; activation of protein kinase activity; heart development; inhibition of NF-kappaB transcription factor; negative regulation of caspase activity; negative regulation of heterotypic cell-cell adhesion; negative regulation of interleukin-8 biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; nerve growth factor receptor signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of cell growth; positive regulation of epithelial cell proliferation; positive regulation of protein metabolic process; positive regulation of transcription from RNA polymerase II promoter; regulation of apoptosis; regulation of mitotic cell cycle; signal transduction; stress-activated protein kinase signaling pathway |
NCBI Summary: | The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011] |
UniProt Code: | Q13163 |
NCBI GenInfo Identifier: | 118572669 |
NCBI Gene ID: | 5607 |
NCBI Accession: | Q13163.2 |
UniProt Secondary Accession: | Q13163,Q92961, Q92962, B4DE43, |
UniProt Related Accession: | Q13163 |
Molecular Weight: | 46,131 Da |
NCBI Full Name: | Dual specificity mitogen-activated protein kinase kinase 5 |
NCBI Synonym Full Names: | mitogen-activated protein kinase kinase 5 |
NCBI Official Symbol: | MAP2K5 |
NCBI Official Synonym Symbols: | MEK5; MAPKK5; PRKMK5; HsT17454 |
NCBI Protein Information: | dual specificity mitogen-activated protein kinase kinase 5 |
UniProt Protein Name: | Dual specificity mitogen-activated protein kinase kinase 5 |
UniProt Synonym Protein Names: | MAPK/ERK kinase 5; MEK 5 |
Protein Family: | Dual specificity mitogen-activated protein kinase kinase |
UniProt Gene Name: | MAP2K5 |
UniProt Entry Name: | MP2K5_HUMAN |