UniProt Protein Function: | LC3C: is a ubiquitin-like protein that is a constituent of the ATG8-conjugation system, one of two evolutionarily conserved phosphatidylethanolamine conjugation systems necessary for the formation of the autophagosome. The human ATG8 system includes seven ubiquitin-like light chain proteins (LCPs) that are homologs of yeast LC3: MAP1LC3A, -B, -C, GABARAP, GABARAPL1, -2, and -3. Pro-LCPs are cleaved by ATG4B to expose a C-terminal glycine residue, the cytosolic LCP-I form. The exposed C-terminus is conjugated to the head group amine of phosphatidylethanolamine (PE) through an amide bond by a sequence of ubiquitination-like reactions that involves an E1 (ATG7), an E2 (ATG3), and an E3 (a complex including ATG5, ATG12, and ATG16L). The PE-congugated form (LCP-II) is tightly associated with the autophagosomal membrane. The LCP-II forms can also be delipidated by the ATG4 proteases: most of the LCPs are delipidated and liberated from the membrane before autophagosomes fuse with lysosomes. |
UniProt Protein Details: | Protein type:Vesicle; Autophagy; Microtubule-binding; Ubiquitin-like modifier Chromosomal Location of Human Ortholog: 1q43 Cellular Component: microtubule; extrinsic to membrane; endomembrane system; autophagic vacuole; cytoplasmic vesicle; cytosol Molecular Function:protein binding; microtubule binding; GABA receptor binding Biological Process: mitochondrion degradation; autophagic vacuole formation; cellular response to nitrogen starvation |
NCBI Summary: | Autophagy is a highly regulated bulk degradation process that plays an important role in cellular maintenance and development. MAP1LC3C is an ortholog of the yeast autophagosome protein Atg8 (He et al., 2003 [PubMed 12740394]).[supplied by OMIM, Nov 2010] |
UniProt Code: | Q9BXW4 |
NCBI GenInfo Identifier: | 84028113 |
NCBI Gene ID: | 440738 |
NCBI Accession: | Q9BXW4.1 |
UniProt Secondary Accession: | Q9BXW4,A0PJY8, A2RUP0, |
UniProt Related Accession: | Q9BXW4 |
Molecular Weight: | 16,852 Da |
NCBI Full Name: | Microtubule-associated proteins 1A/1B light chain 3C |
NCBI Synonym Full Names: | microtubule-associated protein 1 light chain 3 gamma |
NCBI Official Symbol: | MAP1LC3C |
NCBI Official Synonym Symbols: | LC3C; ATG8J |
NCBI Protein Information: | microtubule-associated proteins 1A/1B light chain 3C; LC3-like protein 2; MAP1 light chain 3-like protein 2; MAP1 light chain 3-like protein 3; MAP1A/MAP1B LC3 C; MAP1A/MAP1B light chain 3 C; autophagy-related protein LC3 C; autophagy-related ubiquitin-like modifier LC3 C |
UniProt Protein Name: | Microtubule-associated proteins 1A/1B light chain 3C |
UniProt Synonym Protein Names: | Autophagy-related protein LC3 C; Autophagy-related ubiquitin-like modifier LC3 C; MAP1 light chain 3-like protein 3; MAP1A/MAP1B light chain 3 C; MAP1A/MAP1B LC3 C; Microtubule-associated protein 1 light chain 3 gamma |
Protein Family: | Microtubule-associated protein |
UniProt Gene Name: | MAP1LC3C |
UniProt Entry Name: | MLP3C_HUMAN |