LRPAP1 Antibody (PACO62939)
- SKU:
- PACO62939
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | LRPAP1 Antibody (PACO62939) |
抗体コード: | PACO62939 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
反応性: | Human |
免疫原: | Recombinant Human Alpha-2-macroglobulin receptor-associated protein (35-357AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: THP-1 whole cell lysate, A375 whole cell lysate. All lanes: LRPAP1 antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 42 kDa. Observed band size: 42 kDa. |
バックグラウンド: | Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway. |
シノニム: | Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP), LRPAP1, A2MRAP |
UniProt Protein Function: | LRPAP1: Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis. Belongs to the alpha-2-MRAP family. |
UniProt Protein Details: | Protein type:Receptor, misc. Chromosomal Location of Human Ortholog: 4p16.3 Cellular Component: cell surface; endoplasmic reticulum; extracellular region; plasma membrane; integral to membrane; vesicle Molecular Function:heparin binding; receptor antagonist activity; protein binding; low-density lipoprotein receptor binding; unfolded protein binding; asialoglycoprotein receptor activity Biological Process: vesicle-mediated transport; receptor-mediated endocytosis; protein folding; negative regulation of protein binding Disease: Myopia 23, Autosomal Recessive |
NCBI Summary: | This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013] |
UniProt Code: | P30533 |
NCBI GenInfo Identifier: | 231539 |
NCBI Gene ID: | 4043 |
NCBI Accession: | P30533.1 |
UniProt Related Accession: | P30533 |
Molecular Weight: | |
NCBI Full Name: | Alpha-2-macroglobulin receptor-associated protein |
NCBI Synonym Full Names: | LDL receptor related protein associated protein 1 |
NCBI Official Symbol: | LRPAP1 |
NCBI Official Synonym Symbols: | RAP; MRAP; A2RAP; HBP44; MYP23; A2MRAP; alpha-2-MRAP |
NCBI Protein Information: | alpha-2-macroglobulin receptor-associated protein |
UniProt Protein Name: | Alpha-2-macroglobulin receptor-associated protein |
UniProt Synonym Protein Names: | Low density lipoprotein receptor-related protein-associated protein 1; RAP |
UniProt Gene Name: | LRPAP1 |
UniProt Entry Name: | AMRP_HUMAN |