LOX Antibody (PACO33752)
- SKU:
- PACO33752
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | LOX Antibody (PACO33752) |
抗体コード: | PACO33752 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:200-1:500 |
反応性: | Human |
免疫原: | Recombinant Human Protein-lysine 6-oxidase protein (174-417AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot Positive WB detected in: A549 whole cell lysate, MCF-7 whole cell lysate All lanes: LOX antibody at 3.6µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 47 kDa Observed band size: 47 kDa . |
![]() | IHC image of PACO33752 diluted at 1:200 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
バックグラウンド: | Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity). |
シノニム: | Protein-lysine 6-oxidase (EC 1.4.3.13) (Lysyl oxidase), LOX |
UniProt Protein Function: | LOX: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression. Belongs to the lysyl oxidase family. |
UniProt Protein Details: | Protein type:EC 1.4.3.13; Secreted; Secreted, signal peptide; Oxidoreductase Chromosomal Location of Human Ortholog: 5q23.2 Cellular Component: extracellular region Molecular Function:protein binding Biological Process: extracellular matrix organization and biogenesis; protein modification process Disease: Cutis Laxa, Autosomal Recessive, Type Ia |
NCBI Summary: | This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016] |
UniProt Code: | P28300 |
NCBI GenInfo Identifier: | 417269 |
NCBI Gene ID: | 4015 |
NCBI Accession: | P28300.2 |
UniProt Secondary Accession: | P28300,Q5FWF0, B2R5Q3, |
UniProt Related Accession: | P28300 |
Molecular Weight: | 46,944 Da |
NCBI Full Name: | Protein-lysine 6-oxidase |
NCBI Synonym Full Names: | lysyl oxidase |
NCBI Official Symbol: | LOX |
NCBI Protein Information: | protein-lysine 6-oxidase |
UniProt Protein Name: | Protein-lysine 6-oxidase |
UniProt Synonym Protein Names: | Lysyl oxidase |
Protein Family: | Linoleate 9/13-lipoxygenase |
UniProt Gene Name: | LOX |
UniProt Entry Name: | LYOX_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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