LMO2 Antibody, FITC conjugated (PACO45984)
- SKU:
- PACO45984
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | LMO2 Antibody, FITC conjugated (PACO45984) |
抗体コード: | PACO45984 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Rhombotin-2 protein (1-100AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state. |
シノニム: | Rhombotin-2 (Cysteine-rich protein TTG-2) (LIM domain only protein 2) (LMO-2) (T-cell translocation protein 2), LMO2, RBTN2 RBTNL1 RHOM2 TTG2 |
UniProt Protein Function: | LMO2: Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state. A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Adaptor/scaffold; Oncoprotein Chromosomal Location of Human Ortholog: 11p13 Cellular Component: transcription factor complex; nucleus Molecular Function:protein binding; zinc ion binding; bHLH transcription factor binding; chromatin binding; cofactor binding Biological Process: negative regulation of erythrocyte differentiation; embryonic hemopoiesis; multicellular organismal development; positive regulation of transcription from RNA polymerase II promoter; mRNA transcription from RNA polymerase II promoter |
NCBI Summary: | LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2008] |
UniProt Code: | P25791 |
NCBI GenInfo Identifier: | 132533 |
NCBI Gene ID: | 4005 |
NCBI Accession: | P25791.1 |
UniProt Related Accession: | P25791 |
Molecular Weight: | 18.4kDa |
NCBI Full Name: | Rhombotin-2 |
NCBI Synonym Full Names: | LIM domain only 2 |
NCBI Official Symbol: | LMO2 |
NCBI Official Synonym Symbols: | TTG2; LMO-2; RBTN2; RHOM2; RBTNL1 |
NCBI Protein Information: | rhombotin-2 |
UniProt Protein Name: | Rhombotin-2 |
UniProt Synonym Protein Names: | Cysteine-rich protein TTG-2; LIM domain only protein 2; LMO-2; T-cell translocation protein 2 |
Protein Family: | Rhombotin |
UniProt Gene Name: | LMO2 |
UniProt Entry Name: | RBTN2_HUMAN |