UniProt Protein Function: | LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes. |
NCBI Summary: | The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012] |
UniProt Code: | P15018 |
NCBI GenInfo Identifier: | 126279 |
NCBI Gene ID: | 3976 |
NCBI Accession: | P15018.1 |
UniProt Secondary Accession: | P15018,Q52LZ2, B2RCW7, B5MC23, |
UniProt Related Accession: | P15018 |
Molecular Weight: | 9,563 Da |
NCBI Full Name: | Leukemia inhibitory factor |
NCBI Synonym Full Names: | LIF, interleukin 6 family cytokine |
NCBI Official Symbol: | LIF |
NCBI Official Synonym Symbols: | CDF; DIA; HILDA; MLPLI |
NCBI Protein Information: | leukemia inhibitory factor |
UniProt Protein Name: | Leukemia inhibitory factor |
UniProt Synonym Protein Names: | Differentiation-stimulating factor; D factor; Melanoma-derived LPL inhibitor; MLPLI; INN: Emfilermin |
Protein Family: | Leukemia inhibitory factor |
UniProt Gene Name: | LIF |