LEFTY2 Antibody (PACO17227)
- SKU:
- PACO17227
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | LEFTY2 Antibody (PACO17227) |
抗体コード: | PACO17227 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:10-1:50 |
反応性: | Human, Mouse |
免疫原: | Full length fusion protein |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO17227(LEFTY2 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
![]() | Gel: 8%SDS-PAGE,Lysate: 40 μg,,Primary antibody: PACO17227(LEFTY2 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 30 seconds. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17227(LEFTY2 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | This gene encodes a member of the TGF-β family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants. |
シノニム: | left-right determination factor 2 |
UniProt Protein Function: | LEFTY2: Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding. Defects in LEFTY2 are the cause of left-right axis malformations (LRAM). The defect includes left pulmonary isomerism, with cardiac anomalies characterized by complete atrioventricular canal defect and hypoplastic left ventricle, and interrupted inferior vena cava. Belongs to the TGF-beta family. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Ligand, receptor tyrosine kinase; Cytokine; Secreted Chromosomal Location of Human Ortholog: 1q42.1 Cellular Component: extracellular matrix; extracellular space; extracellular region Molecular Function:growth factor activity; cytokine activity; transforming growth factor beta receptor binding Biological Process: regulation of apoptosis; platelet activation; platelet degranulation; regulation of MAPKKK cascade; multicellular organismal development; transforming growth factor beta receptor signaling pathway; cell growth; blood coagulation; cell development |
NCBI Summary: | This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2010] |
UniProt Code: | O00292 |
NCBI GenInfo Identifier: | 27436881 |
NCBI Gene ID: | 7044 |
NCBI Accession: | NP_003231.2 |
UniProt Secondary Accession: | O00292,O75611, Q5TE89, Q8NBQ9, B3KNH4, B4E332, E9PDM4 |
UniProt Related Accession: | O00292 |
Molecular Weight: | 37,093 Da |
NCBI Full Name: | left-right determination factor 2 isoform 1 preproprotein |
NCBI Synonym Full Names: | left-right determination factor 2 |
NCBI Official Symbol: | LEFTY2 |
NCBI Official Synonym Symbols: | EBAF; LEFTA; TGFB4; LEFTYA |
NCBI Protein Information: | left-right determination factor 2; TGF-beta-4; protein lefty-2; protein lefty-A; left-right determination factor A; transforming growth factor beta-4; endometrial bleeding-associated factor |
UniProt Protein Name: | Left-right determination factor 2 |
UniProt Synonym Protein Names: | Endometrial bleeding-associated factor; Left-right determination factor A; Protein lefty-2; Protein lefty-A; Transforming growth factor beta-4; TGF-beta-4 |
UniProt Gene Name: | LEFTY2 |
UniProt Entry Name: | LFTY2_HUMAN |