LCP1 Antibody (PACO27917)
- SKU:
- PACO27917
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | LCP1 Antibody (PACO27917) |
抗体コード: | PACO27917 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human, Mouse |
免疫原: | Recombinant Human Plastin-2 protein (2-627AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot Positive WB detected in: HL60 whole cell lysate, THP-1 whole cell lysate, K562 whole cell lysate, Jurkat whole cell lysate, Hela whole cell lysate, NIH/3T3 whole cell lysate All lanes: LCP1 antibody at 8µg/ml Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 71, 22 kDa Observed band size: 71 kDa . |
![]() | Immunofluorescent analysis of A549 cells using PACO27917 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
![]() | Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO27917 at dilution of 1:100. |
バックグラウンド: | Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69. |
シノニム: | Plastin-2 (L-plastin) (LC64P) (Lymphocyte cytosolic protein 1) (LCP-1), LCP1, PLS2 |
UniProt Protein Function: | L-plastin: Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69. Monomer. Interacts with AIF1. Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T- lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Actin-binding Chromosomal Location of Human Ortholog: 13q14.3 Cellular Component: actin cytoskeleton; actin filament; actin filament bundle; cytoplasm; cytosol; extracellular space; filopodium; focal adhesion; plasma membrane; podosome; ruffle; stress fiber Molecular Function:actin filament binding; GTPase binding Biological Process: actin filament bundle formation; cell migration; extracellular matrix disassembly; regulation of intracellular protein transport; T cell activation during immune response |
NCBI Summary: | Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues. [provided by RefSeq, Jul 2008] |
UniProt Code: | P13796 |
NCBI GenInfo Identifier: | 308153685 |
NCBI Gene ID: | 3936 |
NCBI Accession: | P13796.6 |
UniProt Secondary Accession: | P13796,Q5TBN4, B2R613, B4DUA0, |
UniProt Related Accession: | P13796 |
Molecular Weight: | 21,792 Da |
NCBI Full Name: | Plastin-2 |
NCBI Synonym Full Names: | lymphocyte cytosolic protein 1 |
NCBI Official Symbol: | LCP1 |
NCBI Official Synonym Symbols: | LPL; CP64; PLS2; LC64P; HEL-S-37; L-PLASTIN |
NCBI Protein Information: | plastin-2 |
UniProt Protein Name: | Plastin-2 |
UniProt Synonym Protein Names: | L-plastin; LC64P; Lymphocyte cytosolic protein 1; LCP-1 |
Protein Family: | Larval cuticle protein |
UniProt Gene Name: | LCP1 |
UniProt Entry Name: | PLSL_HUMAN |