LAMTOR1 Antibody, FITC conjugated (PACO59159)
- SKU:
- PACO59159
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | LAMTOR1 Antibody, FITC conjugated (PACO59159) |
抗体コード: | PACO59159 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Ragulator complex protein LAMTOR1 protein (2-161AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | As part of the Ragulator complex it is involved in amino acid, sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acid,. Activated by amino acid, through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation. |
シノニム: | Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho), LAMTOR1, C11orf59 PDRO |
UniProt Protein Function: | LAMTOR1: Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, recruits the Rag GTPases and the mTORC1 complex to lysosomes, a key step in activation of the TOR signaling cascade by amino acids. Directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation. Part of the Ragulator complex composed of LAMTOR1, LAMTOR2 and LAMTOR3. Interacts with LAMTOR2 and LAMTOR3; the interaction is direct. The Ragulator complex interacts with both the mTORC1 complex and heterodimers of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD. Interacts with RRAGB and RRAGD; the interaction is direct indicating that it probably constitutes the main RAG-interacting subunit of the Ragulator complex. Interacts with MMP14. Interacts with CDKN1B; prevents the interaction of CDKN1B with RHOA leaving RHOA in a form accessible to activation by ARHGEF2. |
UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 11q13.4 Cellular Component: late endosome membrane; lipid raft; lysosomal membrane; lysosome; plasma membrane Molecular Function:GTPase binding; guanyl-nucleotide exchange factor activity; protein binding; protein complex scaffold Biological Process: cell cycle arrest; cell growth; cholesterol homeostasis; endosome localization; endosome organization and biogenesis; lysosome localization; lysosome organization and biogenesis; macroautophagy; neutrophil degranulation; positive regulation of MAPKKK cascade; positive regulation of TOR signaling pathway; regulation of receptor recycling |
UniProt Code: | Q6IAA8 |
NCBI GenInfo Identifier: | 125863645 |
NCBI Gene ID: | 55004 |
NCBI Accession: | Q6IAA8.2 |
UniProt Secondary Accession: | Q6IAA8,Q8WZ09, Q9NWT0, |
UniProt Related Accession: | Q6IAA8 |
Molecular Weight: | 18kDa |
NCBI Full Name: | Ragulator complex protein LAMTOR1 |
NCBI Synonym Full Names: | late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 |
NCBI Official Symbol: | LAMTOR1 |
NCBI Official Synonym Symbols: | p18; PDRO; C11orf59; p27RF-Rho; Ragulator1 |
NCBI Protein Information: | ragulator complex protein LAMTOR1 |
UniProt Protein Name: | Ragulator complex protein LAMTOR1 |
UniProt Synonym Protein Names: | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1; Lipid raft adaptor protein p18; Protein associated with DRMs and endosomes; p27Kip1-releasing factor from RhoA; p27RF-Rho |
Protein Family: | Ragulator complex protein |
UniProt Gene Name: | LAMTOR1 |