KRT4 Antibody (PACO27861)
- SKU:
- PACO27861
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | KRT4 Antibody (PACO27861) |
抗体コード: | PACO27861 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Keratin, type II cytoskeletal 4 protein (1-534AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human cervical cancer using PACO27861 at dilution of 1:100. | |
Immunofluorescent analysis of A549 cells using PACO27861 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO27861 at dilution of 1:100. |
シノニム: | Keratin, type II cytoskeletal 4 (Cytokeratin-4) (CK-4) (Keratin-4) (K4) (Type-II keratin Kb4), KRT4, CYK4 |
UniProt Protein Function: | K4: Heterotetramer of two type I and two type II keratins. Keratin-4 is generally associated with keratin-13. Detected in the suprabasal layer of the stratified epithelium of the esophagus, exocervix, vagina, mouth and lingual mucosa, and in cells and cell clusters in the mucosa and serous gland ducts of the esophageal submucosa. Expressed widely in the exocervix and esophageal epithelium, with lowest levels detected in the basal cell layer. Belongs to the intermediate filament family. |
UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 12q13.13 Cellular Component: intermediate filament cytoskeleton; cell surface; keratin filament; intermediate filament; nucleus Molecular Function:protein binding; structural molecule activity Biological Process: epithelial cell differentiation; cytoskeleton organization and biogenesis; negative regulation of epithelial cell proliferation Disease: White Sponge Nevus 1 |
NCBI Summary: | The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008] |
UniProt Code: | P19013 |
NCBI GenInfo Identifier: | 82654947 |
NCBI Gene ID: | 3851 |
NCBI Accession: | P19013.4 |
UniProt Related Accession: | P19013 |
Molecular Weight: | |
NCBI Full Name: | Keratin, type II cytoskeletal 4 |
NCBI Synonym Full Names: | keratin 4 |
NCBI Official Symbol: | KRT4 |
NCBI Official Synonym Symbols: | K4; CK4; CK-4; CYK4; WSN1 |
NCBI Protein Information: | keratin, type II cytoskeletal 4 |
UniProt Protein Name: | Keratin, type II cytoskeletal 4 |
UniProt Synonym Protein Names: | Cytokeratin-4; CK-4; Keratin-4; K4; Type-II keratin Kb4 |
UniProt Gene Name: | KRT4 |
UniProt Entry Name: | K2C4_HUMAN |