KPNA4 Antibody, FITC conjugated (PACO48996)
- SKU:
- PACO48996
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | KPNA4 Antibody, FITC conjugated (PACO48996) |
抗体コード: | PACO48996 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Importin subunit alpha-3 protein (51-239AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-β and the three components separate and importin-α and -β are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. |
シノニム: | Importin subunit alpha-3 (Importin α Q1) (Qip1) (Karyopherin subunit alpha-4), KPNA4, QIP1 |
UniProt Protein Function: | KPNA4: an alpha importin protein that functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Forms a complex with importin beta-1 subunit. |
UniProt Protein Details: | Protein type:Karyopherin; Chaperone; Nuclear import; Adaptor/scaffold Chromosomal Location of Human Ortholog: 3q25.33 Cellular Component: cytosol; nuclear pore; nucleoplasm Molecular Function:nuclear localization sequence binding; protein binding; protein transporter activity Biological Process: modification by virus of host cellular process; NLS-bearing substrate import into nucleus |
NCBI Summary: | The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. [provided by RefSeq, Jul 2008] |
UniProt Code: | O00629 |
NCBI GenInfo Identifier: | 2811003 |
NCBI Gene ID: | 3840 |
NCBI Accession: | O00629.1 |
UniProt Secondary Accession: | O00629,O00190, A8K4S6, D3DNM2, |
UniProt Related Accession: | O00629 |
Molecular Weight: | 57,887 Da |
NCBI Full Name: | Importin subunit alpha-3 |
NCBI Synonym Full Names: | karyopherin subunit alpha 4 |
NCBI Official Symbol: | KPNA4 |
NCBI Official Synonym Symbols: | QIP1; SRP3; IPOA3 |
NCBI Protein Information: | importin subunit alpha-3 |
UniProt Protein Name: | Importin subunit alpha-3 |
UniProt Synonym Protein Names: | Importin alpha Q1; Qip1; Karyopherin subunit alpha-4 |
UniProt Gene Name: | KPNA4 |
UniProt Entry Name: | IMA3_HUMAN |