KLF11 Antibody (PACO55590)
- SKU:
- PACO55590
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | KLF11 Antibody (PACO55590) |
抗体コード: | PACO55590 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Krueppel-like factor 11 protein (107-205AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | IHC image of PACO55590 diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
バックグラウンド: | Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-β signaling (By similarity). Induces apoptosis (By similarity). |
シノニム: | Krueppel-like factor 11 (Transforming growth factor-beta-inducible early growth response protein 2) (TGFB-inducible early growth response protein 2) (TIEG-2), KLF11, FKLF TIEG2 |
UniProt Protein Function: | TIEG2: Transcription factor. Activates the epsilon- and gamma- globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis. Defects in KLF11 are the cause of maturity-onset diabetes of the young type 7 (MODY7). MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. Belongs to the Sp1 C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:DNA-binding; C2H2-type zinc finger protein; Transcription factor Chromosomal Location of Human Ortholog: 2p25 Molecular Function:protein binding; transcription factor activity Biological Process: G1/S-specific transcription in mitotic cell cycle; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of apoptosis; transcription from RNA polymerase II promoter Disease: Maturity-onset Diabetes Of The Young, Type 7 |
NCBI Summary: | The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010] |
UniProt Code: | O14901 |
NCBI GenInfo Identifier: | 11387048 |
NCBI Gene ID: | 8462 |
NCBI Accession: | O14901.2 |
UniProt Secondary Accession: | O14901,Q9EPF4, B4DZE7, |
UniProt Related Accession: | O14901 |
Molecular Weight: | 53,329 Da |
NCBI Full Name: | Krueppel-like factor 11 |
NCBI Synonym Full Names: | Kruppel like factor 11 |
NCBI Official Symbol: | KLF11 |
NCBI Official Synonym Symbols: | FKLF; FKLF1; MODY7; TIEG2; Tieg3 |
NCBI Protein Information: | Krueppel-like factor 11 |
UniProt Protein Name: | Krueppel-like factor 11 |
UniProt Synonym Protein Names: | Transforming growth factor-beta-inducible early growth response protein 2; TGFB-inducible early growth response protein 2; TIEG-2 |
Protein Family: | Krueppel-like factor |
UniProt Gene Name: | KLF11 |
UniProt Entry Name: | KLF11_HUMAN |
Antibodies | ELISA Kits |
Anti-KLF11 Antibody (CAB18659) | KLF11 Colorimetric Cell-Based ELISA |
KLF11 Antibody (PACO01625) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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