KLF11 Antibody (PACO01625)
- SKU:
- PACO01625
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | KLF11 Antibody |
抗体コード: | PACO01625 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF |
推奨される希釈: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
反応性: | Human, Mouse |
免疫原: | synthesized peptide derived from the N-terminal region of human TIEG2. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | KLF11; FKLF; TIEG2; Krueppel-like factor 11; Transforming growth factor-beta-inducible early growth response protein 2; TGFB-inducible early growth response protein 2; TIEG-2 |
UniProt Protein Function: | TIEG2: Transcription factor. Activates the epsilon- and gamma- globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis. Defects in KLF11 are the cause of maturity-onset diabetes of the young type 7 (MODY7). MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. Belongs to the Sp1 C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:DNA-binding; C2H2-type zinc finger protein; Transcription factor Chromosomal Location of Human Ortholog: 2p25 Molecular Function:protein binding; transcription factor activity Biological Process: G1/S-specific transcription in mitotic cell cycle; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of apoptosis; transcription from RNA polymerase II promoter Disease: Maturity-onset Diabetes Of The Young, Type 7 |
NCBI Summary: | The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010] |
UniProt Code: | O14901 |
NCBI GenInfo Identifier: | 11387048 |
NCBI Gene ID: | 8462 |
NCBI Accession: | O14901.2 |
UniProt Secondary Accession: | O14901,Q9EPF4, B4DZE7, |
UniProt Related Accession: | O14901 |
Molecular Weight: | 53,329 Da |
NCBI Full Name: | Krueppel-like factor 11 |
NCBI Synonym Full Names: | Kruppel like factor 11 |
NCBI Official Symbol: | KLF11 |
NCBI Official Synonym Symbols: | FKLF; FKLF1; MODY7; TIEG2; Tieg3 |
NCBI Protein Information: | Krueppel-like factor 11 |
UniProt Protein Name: | Krueppel-like factor 11 |
UniProt Synonym Protein Names: | Transforming growth factor-beta-inducible early growth response protein 2; TGFB-inducible early growth response protein 2; TIEG-2 |
Protein Family: | Krueppel-like factor |
UniProt Gene Name: | KLF11 |
UniProt Entry Name: | KLF11_HUMAN |