KISS1R Antibody (PACO18037)
- SKU:
- PACO18037
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| 抗体名: | KISS1R Antibody (PACO18037) |
| 抗体コード: | PACO18037 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
| 反応性: | Human |
| 免疫原: | Synthetic peptide of human KISS1R |
| 憲法: | Liquid |
| ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| 精製方法: | Antigen affinity purification |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO18037(KISS1R Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Jurkat cells, Hela cells, 231 cells, Primary antibody: PACO18037(KISS1R Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO18037(KISS1R Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200). |
| バックグラウンド: | The protein encoded by this gene is a galanin-like G protein-coupled receptor that binds metastin, a peptide encoded by the metastasis suppressor gene KISS1. The tissue distribution of the expressed gene suggests that it is involved in the regulation of endocrine function, and this is supported by the finding that this gene appears to play a role in the onset of puberty. Mutations in this gene have been associated with hypogonadotropic hypogonadism and central precocious puberty. |
| シノニム: | KISS1 receptor |
| UniProt Protein Function: | KISS1R: Receptor for metastin (kisspeptin-54 or kp-54), a C- terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine- tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins. Defects in KISS1R are a cause of idiopathic hypogonadotropic hypogonadism (IHH). IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. Defects in KISS1R are a cause of central precocious puberty (CEPREPU). Precocious puberty is defined as the development of secondary sexual characteristics before the age of 8 years in girls and 9 years in boys. Central precocious puberty refers to a gonadotropin-dependent type which results from premature activation of the hypothalamic-pituitary-gonadal axis. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: integral to membrane; integral to plasma membrane; intracellular membrane-bound organelle; plasma membrane Molecular Function:neuropeptide receptor activity; protein binding Biological Process: G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) Disease: Hypogonadotropic Hypogonadism 8 With Or Without Anosmia; Precocious Puberty, Central, 1 |
| NCBI Summary: | The protein encoded by this gene is a galanin-like G protein-coupled receptor that binds metastin, a peptide encoded by the metastasis suppressor gene KISS1. The tissue distribution of the expressed gene suggests that it is involved in the regulation of endocrine function, and this is supported by the finding that this gene appears to play a role in the onset of puberty. Mutations in this gene have been associated with hypogonadotropic hypogonadism and central precocious puberty. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q969F8 |
| NCBI GenInfo Identifier: | 125987836 |
| NCBI Gene ID: | 84634 |
| NCBI Accession: | Q969F8.2 |
| UniProt Secondary Accession: | Q969F8,Q96QG0, A5D8U2, B2RTV1, |
| UniProt Related Accession: | Q969F8 |
| Molecular Weight: | 42,586 Da |
| NCBI Full Name: | KiSS-1 receptor |
| NCBI Synonym Full Names: | KISS1 receptor |
| NCBI Official Symbol: | KISS1R |
| NCBI Official Synonym Symbols: | HH8; CPPB1; GPR54; AXOR12; KISS-1R; HOT7T175 |
| NCBI Protein Information: | kiSS-1 receptor |
| UniProt Protein Name: | KiSS-1 receptor |
| UniProt Synonym Protein Names: | G-protein coupled receptor 54; G-protein coupled receptor OT7T175; hOT7T175; Hypogonadotropin-1; Kisspeptins receptor; Metastin receptor |
| Protein Family: | KiSS-1 receptor |
| UniProt Gene Name: | KISS1R |
| UniProt Entry Name: | KISSR_HUMAN |
| Antibodies | ELISA Kits |
| Anti-KISS1R Antibody (CAB2967) | Human KiSS1R / GPR54 ELISA Kit |
| KISS1R Antibody (PACO05528) | Human KiSS-1 receptor (KISS1R) ELISA Kit |
| KISS1R Antibody (PACO10116) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |