KIR3DL1 Antibody, FITC conjugated (PACO51680)
- SKU:
- PACO51680
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | KIR3DL1 Antibody, FITC conjugated (PACO51680) |
抗体コード: | PACO51680 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Killer cell immunoglobulin-like receptor 3DL1 protein (81-336AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis. |
シノニム: | Killer cell immunoglobulin-like receptor 3DL1 (CD158 antigen-like family member E) (HLA-BW4-specific inhibitory NK cell receptor) (MHC class I NK cell receptor) (Natural killer-associated transcript 3) (NKAT-3) (p70 natural killer cell receptor clones CL-2/CL-11) (p70 NK receptor CL-2/CL-11) (CD antigen CD158e), KIR3DL1, CD158E NKAT3 NKB1 |
UniProt Protein Function: | KIR3DL1: Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis. Belongs to the immunoglobulin superfamily. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 19q13.4 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:HLA-B specific inhibitory MHC class I receptor activity Biological Process: regulation of immune response; immune response; signal transduction Disease: Human Immunodeficiency Virus Type 1, Susceptibility To |
NCBI Summary: | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] |
UniProt Code: | P43629 |
NCBI GenInfo Identifier: | 1171728 |
NCBI Gene ID: | 3811 |
NCBI Accession: | P43629.1 |
UniProt Related Accession: | P43629 |
Molecular Weight: | |
NCBI Full Name: | Killer cell immunoglobulin-like receptor 3DL1 |
NCBI Synonym Full Names: | killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1 |
NCBI Official Symbol: | KIR3DL1 |
NCBI Official Synonym Symbols: | KIR; NKB1; NKAT3; NKB1B; NKAT-3; CD158E1; KIR3DL1/S1 |
NCBI Protein Information: | killer cell immunoglobulin-like receptor 3DL1 |
UniProt Protein Name: | Killer cell immunoglobulin-like receptor 3DL1 |
UniProt Synonym Protein Names: | CD158 antigen-like family member E; HLA-BW4-specific inhibitory NK cell receptor; MHC class I NK cell receptor; Natural killer-associated transcript 3; NKAT-3; p70 natural killer cell receptor clones CL-2/CL-11; p70 NK receptor CL-2/CL-11; CD_antigen: CD158e |
UniProt Gene Name: | KIR3DL1 |
UniProt Entry Name: | KI3L1_HUMAN |