KIF14 Antibody (PACO48570)
- SKU:
- PACO48570
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | KIF14 Antibody (PACO48570) |
抗体コード: | PACO48570 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Kinesin-like protein KIF14 protein (261-531AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO48570 at dilution of 1:100. | |
Immunofluorescent analysis of HepG2 cells using PACO48570 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human heart tissue using PACO48570 at dilution of 1:100. |
バックグラウンド: | Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis. During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively. Regulates cell growth through regulation of cell cycle progression and cytokinesis. During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1. During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process. Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules. |
シノニム: | Kinesin-like protein KIF14, KIF14, KIAA0042 |
UniProt Protein Function: | KIF14: Plays an essential role in cytokinesis. Belongs to the kinesin-like protein family. |
UniProt Protein Details: | Protein type:Microtubule-binding; Motor Chromosomal Location of Human Ortholog: 1q32.1 Cellular Component: cytosol; kinesin complex; membrane; microtubule; midbody; plasma membrane; spindle midzone Molecular Function:ATP binding; ATPase activity; microtubule binding; microtubule motor activity; PDZ domain binding; plus-end-directed microtubule motor activity; protein binding; protein kinase binding; tubulin binding Biological Process: activation of protein kinase activity; cell proliferation in forebrain; cerebellar cortex development; cerebellar granular layer structural organization; cerebellar Purkinje cell layer structural organization; cerebral cortex development; establishment of protein localization; hippocampus development; microtubule depolymerization; microtubule-based movement; mitotic metaphase plate congression; negative regulation of apoptosis; negative regulation of integrin activation; negative regulation of neuron apoptosis; olfactory bulb development; positive regulation of cell proliferation; positive regulation of cytokinesis; proteasomal ubiquitin-dependent protein catabolic process; regulation of cell adhesion; regulation of cell growth; regulation of cell migration; regulation of G2/M transition of mitotic cell cycle; regulation of myelination; regulation of neuron apoptosis; regulation of Rap protein signal transduction; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Disease: Meckel Syndrome 12 |
NCBI Summary: | This gene encodes a member of the kinesin-3 superfamily of microtubule motor proteins. These proteins are involved in numerous processes including vesicle transport, chromosome segregation, mitotic spindle formation, and cytokinesis. In human HeLa-S3 and 293T cells, this protein is localized to the cytoplasm during interphase, to the spindle poles and spindle microtubules during mitosis, and to the midbody during cytokinesis. An internal motor domain displays microtubule-dependent ATPase activity, consistent with its function as a microtubule motor protein. Knockdown of this gene results in failed cytokinesis with endoreplication, which results in multinucleated cells. This gene has been identified as a likely oncogene in breast, lung and ovarian cancers, as well as retinoblastomas and gliomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015] |
UniProt Code: | Q15058 |
NCBI GenInfo Identifier: | 23396633 |
NCBI Gene ID: | 9928 |
NCBI Accession: | Q15058.1 |
UniProt Secondary Accession: | Q15058,Q14CI8, Q4G0A5, Q5T1W3, |
UniProt Related Accession: | Q15058 |
Molecular Weight: | 186kDa |
NCBI Full Name: | Kinesin-like protein KIF14 |
NCBI Synonym Full Names: | kinesin family member 14 |
NCBI Official Symbol: | KIF14 |
NCBI Official Synonym Symbols: | MKS12 |
NCBI Protein Information: | kinesin-like protein KIF14 |
UniProt Protein Name: | Kinesin-like protein KIF14 |
Protein Family: | Kinesin-like protein |
UniProt Gene Name: | KIF14 |
Antibodies |
Anti-KIF14 Antibody (CAB10275) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |