KHDRBS2 Antibody, FITC conjugated (PACO36556)
- SKU:
- PACO36556
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | KHDRBS2 Antibody, FITC conjugated (PACO36556) |
抗体コード: | PACO36556 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human KH domain-containing, RNA-binding, signal transduction-associated protein 2 protein (1-349AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity). Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergystically with SAM68 in exon skipping. In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. May function as an adapter protein for Src kinases during mitosis. |
シノニム: | KH domain-containing, RNA-binding, signal transduction-associated protein 2 (Sam68-like mammalian protein 1) (SLM-1) (hSLM-1), KHDRBS2, SLM1 |
UniProt Protein Function: | KHDRBS2: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. May function as an adapter protein for Src kinases during mitosis. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability. Belongs to the KHDRBS family. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 6q11.1 Cellular Component: nucleoplasm Molecular Function:protein binding |
UniProt Code: | Q5VWX1 |
NCBI GenInfo Identifier: | 74762274 |
NCBI Gene ID: | 202559 |
NCBI Accession: | Q5VWX1.1 |
UniProt Secondary Accession: | Q5VWX1,Q8N4I4, Q8TCZ4, A8K7M8, |
UniProt Related Accession: | Q5VWX1 |
Molecular Weight: | 38,927 Da |
NCBI Full Name: | KH domain-containing, RNA-binding, signal transduction-associated protein 2 |
NCBI Synonym Full Names: | KH RNA binding domain containing, signal transduction associated 2 |
NCBI Official Symbol: | KHDRBS2 |
NCBI Official Synonym Symbols: | SLM1; SLM-1 |
NCBI Protein Information: | KH domain-containing, RNA-binding, signal transduction-associated protein 2 |
UniProt Protein Name: | KH domain-containing, RNA-binding, signal transduction-associated protein 2 |
UniProt Synonym Protein Names: | Sam68-like mammalian protein 1; SLM-1; hSLM-1 |
Protein Family: | KH domain-containing, RNA-binding, signal transduction-associated protein |
UniProt Gene Name: | KHDRBS2 |
UniProt Entry Name: | KHDR2_HUMAN |