KDM8 Antibody, Biotin conjugated (PACO38785)
- SKU:
- PACO38785
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | KDM8 Antibody, Biotin conjugated (PACO38785) |
抗体コード: | PACO38785 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human JmjC domain-containing protein 5 protein (151-380AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation. |
シノニム: | JmjC domain-containing protein 5 (EC 1.14.11.27) (EC 3.4.-.-) (Jumonji domain-containing protein 5) (Lysine-specific demethylase 8), KDM8, JMJD5 |
UniProt Protein Function: | JMJD5: Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cell cycle regulation; Demethylase; EC 1.14.11.27 Chromosomal Location of Human Ortholog: 16p12.1 Cellular Component: cytosol; nucleoplasm; nucleus Molecular Function:chromatin binding; histone demethylase activity; histone demethylase activity (H3-K36 specific) Biological Process: G2/M transition of mitotic cell cycle; positive regulation of transcription, DNA-dependent |
NCBI Summary: | This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009] |
UniProt Code: | Q8N371 |
NCBI GenInfo Identifier: | 74728780 |
NCBI Gene ID: | 79831 |
NCBI Accession: | Q8N371.1 |
UniProt Secondary Accession: | Q8N371,Q6VAK5, Q9H8B1, B4DLU9, |
UniProt Related Accession: | Q8N371 |
Molecular Weight: | 47kDa |
NCBI Full Name: | Lysine-specific demethylase 8 |
NCBI Synonym Full Names: | lysine demethylase 8 |
NCBI Official Symbol: | KDM8 |
NCBI Official Synonym Symbols: | JMJD5 |
NCBI Protein Information: | lysine-specific demethylase 8 |
UniProt Protein Name: | Lysine-specific demethylase 8 |
UniProt Synonym Protein Names: | JmjC domain-containing protein 5; Jumonji domain-containing protein 5 |
Protein Family: | Lysine-specific demethylase |
UniProt Gene Name: | KDM8 |