KDM6A Antibody, FITC conjugated (PACO55828)
- SKU:
- PACO55828
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | KDM6A Antibody, FITC conjugated (PACO55828) |
抗体コード: | PACO55828 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Lysine-specific demethylase 6A protein (620-749AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A. |
シノニム: | Lysine-specific demethylase 6A (EC 1.14.11) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein), KDM6A, UTX |
UniProt Protein Function: | UTX: a nuclear protein that contains 8 tetratrico peptide repeat (TPRs). Processes involving TPR proteins include cell-cycle control, transcription repression, stress response, protein kinase inhibition, mitochondrial and peroxisomal protein transport and neurogenesis. Protein type: Oxidoreductase; EC 1.14.11.-Chromosomal Location of Human Ortholog: Xp11.2Cellular Component: histone methyltransferase complex; nucleoplasm; nucleusMolecular Function: histone demethylase activityBiological Process: histone H3-K4 methylationDisease: Kabuki Syndrome 1; Kabuki Syndrome 2 |
UniProt Protein Details: | |
NCBI Summary: | This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014] |
UniProt Code: | O15550 |
NCBI GenInfo Identifier: | 206729942 |
NCBI Gene ID: | 7403 |
NCBI Accession: | O15550.2 |
UniProt Secondary Accession: | O15550,Q52LL9, Q5JVQ7 |
UniProt Related Accession: | O15550 |
Molecular Weight: | 154,177 Da |
NCBI Full Name: | Lysine-specific demethylase 6A |
NCBI Synonym Full Names: | lysine demethylase 6A |
NCBI Official Symbol: | KDM6A |
NCBI Official Synonym Symbols: | UTX; KABUK2; bA386N14.2 |
NCBI Protein Information: | lysine-specific demethylase 6A |
UniProt Protein Name: | Lysine-specific demethylase 6A |
UniProt Synonym Protein Names: | Histone demethylase UTX; Ubiquitously-transcribed TPR protein on the X chromosome; Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein |
Protein Family: | Lysine-specific demethylase |
UniProt Gene Name: | KDM6A |
UniProt Entry Name: | KDM6A_HUMAN |