KDM4C Antibody (PACO19872)
- SKU:
- PACO19872
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | KDM4C Antibody (PACO19872) |
抗体コード: | PACO19872 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:2000-1:5000, WB:1:500-1:2000 |
反応性: | Human, Mouse |
免疫原: | Synthetic peptide of human KDM4C |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse heart tissue, Mouse brain tissue, Primary antibody: PACO19872(KDM4C Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
バックグラウンド: | This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma. Alternative splicing results in multiple transcript variants. |
シノニム: | lysine (K)-specific demethylase 4C |
UniProt Protein Function: | JMJD2C: the histone demethylase implicated in the epigenetic reprogramming during the early embryogenesis. Preferentially expressed in undifferentiated ES cells. JMJD2C, along with JMJD1A, regulate self-renewal in embryonic stem cells. Specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Two isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 1.14.11.-; Oxidoreductase; Demethylase Chromosomal Location of Human Ortholog: 9p24.1 Cellular Component: nuclear chromatin; nucleoplasm Molecular Function:androgen receptor binding; dioxygenase activity; enzyme binding; histone demethylase activity; histone demethylase activity (H3-K9 specific); zinc ion binding Biological Process: histone H3-K9 demethylation; positive regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent |
NCBI Summary: | This gene is a member of the Jumonji domain 2 (JMJD2) family. The encoded protein is a trimethylation-specific demethylase, and converts specific trimethylated histone residues to the dimethylated form. This enzymatic action regulates gene expression and chromosome segregation. Chromosomal aberrations and changes in expression of this gene may be found in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015] |
UniProt Code: | Q9H3R0 |
NCBI GenInfo Identifier: | 97536525 |
NCBI Gene ID: | 23081 |
NCBI Accession: | Q9H3R0.2 |
UniProt Secondary Accession: | Q9H3R0,O94877, Q2M3M0, Q5JUC9, Q5VYJ2, Q5VYJ3, B4E1Y4 B7ZL46, F5H347, F5H7P0, |
UniProt Related Accession: | Q9H3R0 |
Molecular Weight: | 94,376 Da |
NCBI Full Name: | Lysine-specific demethylase 4C |
NCBI Synonym Full Names: | lysine demethylase 4C |
NCBI Official Symbol: | KDM4C |
NCBI Official Synonym Symbols: | GASC1; JHDM3C; JMJD2C; TDRD14C |
NCBI Protein Information: | lysine-specific demethylase 4C |
UniProt Protein Name: | Lysine-specific demethylase 4C |
UniProt Synonym Protein Names: | Gene amplified in squamous cell carcinoma 1 protein; GASC-1 protein; JmjC domain-containing histone demethylation protein 3C; Jumonji domain-containing protein 2C |
UniProt Gene Name: | KDM4C |
UniProt Entry Name: | KDM4C_HUMAN |