KDM4C Antibody, Biotin conjugated (PACO47073)
- SKU:
- PACO47073
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | KDM4C Antibody, Biotin conjugated (PACO47073) |
抗体コード: | PACO47073 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Lysine-specific demethylase 4C protein (450-600AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. |
シノニム: | Lysine-specific demethylase 4C (EC 1.14.11) (Gene amplified in squamous cell carcinoma 1 protein) (GASC-1 protein) (JmjC domain-containing histone demethylation protein 3C) (Jumonji domain-containing protein 2C), KDM4C, GASC1 JHDM3C JMJD2C KIAA0780 |
UniProt Protein Function: | JMJD2C: the histone demethylase implicated in the epigenetic reprogramming during the early embryogenesis. Preferentially expressed in undifferentiated ES cells. JMJD2C, along with JMJD1A, regulate self-renewal in embryonic stem cells. Specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Two isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 1.14.11.-; Oxidoreductase; Demethylase Chromosomal Location of Human Ortholog: 9p24.1 Cellular Component: nuclear chromatin; nucleoplasm Molecular Function:androgen receptor binding; dioxygenase activity; enzyme binding; histone demethylase activity; histone demethylase activity (H3-K9 specific); zinc ion binding Biological Process: histone H3-K9 demethylation; positive regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent |
NCBI Summary: | This gene is a member of the Jumonji domain 2 (JMJD2) family. The encoded protein is a trimethylation-specific demethylase, and converts specific trimethylated histone residues to the dimethylated form. This enzymatic action regulates gene expression and chromosome segregation. Chromosomal aberrations and changes in expression of this gene may be found in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015] |
UniProt Code: | Q9H3R0 |
NCBI GenInfo Identifier: | 97536525 |
NCBI Gene ID: | 23081 |
NCBI Accession: | Q9H3R0.2 |
UniProt Secondary Accession: | Q9H3R0,O94877, Q2M3M0, Q5JUC9, Q5VYJ2, Q5VYJ3, B4E1Y4 B7ZL46, F5H347, F5H7P0, |
UniProt Related Accession: | Q9H3R0 |
Molecular Weight: | 94,376 Da |
NCBI Full Name: | Lysine-specific demethylase 4C |
NCBI Synonym Full Names: | lysine demethylase 4C |
NCBI Official Symbol: | KDM4C |
NCBI Official Synonym Symbols: | GASC1; JHDM3C; JMJD2C; TDRD14C |
NCBI Protein Information: | lysine-specific demethylase 4C |
UniProt Protein Name: | Lysine-specific demethylase 4C |
UniProt Synonym Protein Names: | Gene amplified in squamous cell carcinoma 1 protein; GASC-1 protein; JmjC domain-containing histone demethylation protein 3C; Jumonji domain-containing protein 2C |
UniProt Gene Name: | KDM4C |
UniProt Entry Name: | KDM4C_HUMAN |