KDM3B Antibody (PACO16565)
- SKU:
- PACO16565
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | KDM3B Antibody (PACO16565) |
抗体コード: | PACO16565 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
反応性: | Human, Mouse |
免疫原: | Fusion protein of human KDM3B |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO16565(KDM3B Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO16565(KDM3B Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | JMJD1B (jumonji domain containing 1B), also known as KDM3B, 5qNCA (5q Nuclear Co-Activator) or C5orf7, is a member of the JHDM2 histone demethylase family of proteins. Expressed in a wide variety of tissues, JMJD1B localizes to the nucleus and contains one JMJC domain and a C-terminal zinc finger motif. JMJD1B functions as a histone demethylase and, using iron as a cofactor, demethylates lysine-9 of Histone H3. This suggests that JMJD1B plays a central role in the histone code. The gene encoding human JMJD1B is located within the 5q region of the genome that is often deleted in myeloid leukemias and myelodysplasias. This implies that JMJD1B may function as a tumor suppressor of myeloid leukemia. Eptopic expression of JMJD1B exhibits growth suppressive activities, further supporting a role for JMJD1B in tumor suppression. |
シノニム: | lysine (K)-specific demethylase 3B |
UniProt Protein Function: | JMJD1B: a ubiquitous protein demethylase that specifically demethylates Lys-9 of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. Three alternatively spliced isoforms have been reported.Protein type: EC 1.14.11.-; Oxidoreductase; DemethylaseChromosomal Location of Human Ortholog: 5q31Cellular Component: nucleoplasmMolecular Function: dioxygenase activity; metal ion bindingBiological Process: establishment and/or maintenance of chromatin architecture; regulation of transcription, DNA-dependent; transcription, DNA-dependent; chromatin modification |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | Q7LBC6 |
NCBI GenInfo Identifier: | 308153456 |
NCBI Gene ID: | 51780 |
NCBI Accession: | Q7LBC6.2 |
UniProt Secondary Accession: | Q7LBC6 |
UniProt Related Accession: | Q7LBC6 |
Molecular Weight: | Predicted MW: 29.2kDaAccurate MW: 29kDa |
NCBI Full Name: | Lysine-specific demethylase 3B |
NCBI Synonym Full Names: | lysine demethylase 3B |
NCBI Official Symbol: | KDM3B |
NCBI Official Synonym Symbols: | 5qNCA; NET22; C5orf7; JMJD1B |
NCBI Protein Information: | lysine-specific demethylase 3B |
UniProt Protein Name: | Lysine-specific demethylase 3B |
UniProt Synonym Protein Names: | JmjC domain-containing histone demethylation protein 2B; Jumonji domain-containing protein 1B; Nuclear protein 5qNCA |
Protein Family: | Lysine-specific demethylase |
UniProt Gene Name: | KDM3B |
UniProt Entry Name: | KDM3B_HUMAN |
Antibodies |
KDM3B Antibody (PACO10073) |
Secondary Antibody |
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