KCNV2 Antibody (PACO58384)
- SKU:
- PACO58384
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | KCNV2 Antibody (PACO58384) |
抗体コード: | PACO58384 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:500-1:1000, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Potassium voltage-gated channel subfamily V member 2 protein (1-155AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | IHC image of PACO58384 diluted at 1:500 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
![]() | Immunofluorescence staining of HepG2 cells with PACO58384 at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. |
シノニム: | Potassium voltage-gated channel subfamily V member 2 (Voltage-gated potassium channel subunit Kv8.2), KCNV2 |
UniProt Protein Function: | Kv8.2: Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. Defects in KCNV2 are the cause of cone dystrophy retinal type 3B (RCD3B); also called cone dystrophy with night blindness and supernormal rod responses KCNV2-related. RCD3B is a rare form of cone dystrophy associated with supernormal rod responses. The disorder is characterized by reduced visual acuity, photoaversion, night blindness, and abnormal color vision. At an early age, the retina shows subtle depigmentation at the macula and, later, more obvious areas of atrophy. Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.2/KCNV2 sub-subfamily. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 9p24.2 Cellular Component: integral to membrane; plasma membrane Molecular Function:delayed rectifier potassium channel activity Disease: Retinal Cone Dystrophy 3b |
NCBI Summary: | Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This member is identified as a 'silent subunit', and it does not form homomultimers, but forms heteromultimers with several other subfamily members. Through obligatory heteromerization, it exerts a function-altering effect on other potassium channel subunits. This protein is strongly expressed in pancreas and has a weaker expression in several other tissues. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q8TDN2 |
NCBI GenInfo Identifier: | 26006804 |
NCBI Gene ID: | 169522 |
NCBI Accession: | Q8TDN2.1 |
UniProt Secondary Accession: | Q8TDN2,Q5T6X0, |
UniProt Related Accession: | Q8TDN2 |
Molecular Weight: | 62,459 Da |
NCBI Full Name: | Potassium voltage-gated channel subfamily V member 2 |
NCBI Synonym Full Names: | potassium voltage-gated channel modifier subfamily V member 2 |
NCBI Official Symbol: | KCNV2 |
NCBI Official Synonym Symbols: | Kv8.2; RCD3B; KV11.1 |
NCBI Protein Information: | potassium voltage-gated channel subfamily V member 2 |
UniProt Protein Name: | Potassium voltage-gated channel subfamily V member 2 |
UniProt Synonym Protein Names: | Voltage-gated potassium channel subunit Kv8.2 |
Protein Family: | Potassium voltage-gated channel subfamily |
UniProt Gene Name: | KCNV2 |
UniProt Entry Name: | KCNV2_HUMAN |