KCNK1 Antibody, Biotin conjugated (PACO53301)
- SKU:
- PACO53301
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | KCNK1 Antibody, Biotin conjugated (PACO53301) |
抗体コード: | PACO53301 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Potassium channel subfamily K member 1 protein (268-336AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues. Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acid, fication of the extracellular medium. The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel. Channel activity is modulated by activation of serotonin receptors (By similarity). Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes (By similarity). Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity. Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents. Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential (By similarity). Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability (By similarity). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity). Required for normal ion and water transport in the kidney (By similarity). Contributes to the regulation of the resting membrane potential of pancreatic β cells (By similarity). The low channel activity of homodimeric KCNK1 may be due to sumoylation. The low channel activity may be due to rapid internalization from the cell membrane and retention in recycling endosomes. |
シノニム: | Potassium channel subfamily K member 1 (Inward rectifying potassium channel protein TWIK-1) (Potassium channel K2P1) (Potassium channel KCNO1), KCNK1, HOHO1 KCNO1 TWIK1 |
UniProt Protein Function: | KCNK1: Weakly inward rectifying potassium channel. Homodimer (Potential). Widely expressed with high levels in heart and brain and lower levels in placenta, lung, liver and kidney. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 1q42.2 Cellular Component: integral to membrane; integral to plasma membrane; intracellular membrane-bound organelle; plasma membrane; voltage-gated potassium channel complex Molecular Function:inward rectifier potassium channel activity; potassium channel activity; potassium ion leak channel activity; sodium channel activity; voltage-gated potassium channel activity Biological Process: potassium ion transport; regulation of resting membrane potential |
NCBI Summary: | This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008] |
UniProt Code: | O00180 |
NCBI GenInfo Identifier: | 13124036 |
NCBI Gene ID: | 3775 |
NCBI Accession: | O00180.1 |
UniProt Secondary Accession: | O00180,Q13307, Q5T5E8, |
UniProt Related Accession: | O00180 |
Molecular Weight: | |
NCBI Full Name: | Potassium channel subfamily K member 1 |
NCBI Synonym Full Names: | potassium two pore domain channel subfamily K member 1 |
NCBI Official Symbol: | KCNK1 |
NCBI Official Synonym Symbols: | DPK; HOHO; K2P1; KCNO1; TWIK1; K2p1.1; TWIK-1 |
NCBI Protein Information: | potassium channel subfamily K member 1 |
UniProt Protein Name: | Potassium channel subfamily K member 1 |
UniProt Synonym Protein Names: | Inward rectifying potassium channel protein TWIK-1 |
Protein Family: | Potassium channel subfamily |
UniProt Gene Name: | KCNK1 |