KCNAB1 Antibody (PACO55574)
- SKU:
- PACO55574
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | KCNAB1 Antibody (PACO55574) |
抗体コード: | PACO55574 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:200-1:500, IF:1:50-1:200 |
反応性: | Human, Mouse |
免疫原: | Recombinant Human Voltage-gated potassium channel subunit beta-1 protein (287-401AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: Mouse kidney tissue, U87 whole cell lysate, SH-SY5Y whole cell lysate. All lanes: KCNAB1 antibody at 3.9µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 47, 45, 46 kDa. Observed band size: 60 kDa. |
![]() | IHC image of PACO55574 diluted at 1:200 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
![]() | IHC image of PACO55574 diluted at 1:200 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
バックグラウンド: | Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. Modulates action potentials via its effect on the pore-forming α subunits (By similarity). Promotes expression of the pore-forming α subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members. Promotes the closure of KCNA1, KCNA2 and KCNA5 channels. Accelerates KCNA4 channel closure. Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4. Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity). Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1. Enhances KCNB1 and KCNB2 channel activity (By similarity). Binds NADPH; this is required for efficient down-regulation of potassium channel activity. Has NADPH-dependent aldoketoreductase activity (By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity). |
シノニム: | Voltage-gated potassium channel subunit beta-1 (EC 1.1.1) (K(+) channel subunit beta-1) (Kv-beta-1), KCNAB1, KCNA1B |
UniProt Protein Function: | Kv-beta1: Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. All three isoforms alter the functional properties of Kv1.4 and Kv1.5. Isoform KvB1.2 has no effect on Kv1.1, Kv1.2 or Kv2.1. Belongs to the shaker potassium channel beta subunit family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Channel, potassium Chromosomal Location of Human Ortholog: 3q26.1 Cellular Component: cytosol; extrinsic to internal side of plasma membrane; plasma membrane Molecular Function:aldo-keto reductase activity; potassium channel regulator activity Biological Process: potassium ion transport |
NCBI Summary: | Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes distinct isoforms which are encoded by alternatively spliced transcript variants of this gene. Some of these isoforms are beta subunits, which form heteromultimeric complexes with alpha subunits and modulate the activity of the pore-forming alpha subunits. [provided by RefSeq, Apr 2015] |
UniProt Code: | Q14722 |
NCBI GenInfo Identifier: | 18202500 |
NCBI Gene ID: | 7881 |
NCBI Accession: | Q14722.1 |
UniProt Secondary Accession: | Q14722,Q13031, Q13302, Q16547, Q6PI60, Q99869, A8K9H8 A8KAD4, B3KPZ4, |
UniProt Related Accession: | Q14722 |
Molecular Weight: | 45,492 Da |
NCBI Full Name: | Voltage-gated potassium channel subunit beta-1 |
NCBI Synonym Full Names: | potassium voltage-gated channel subfamily A member regulatory beta subunit 1 |
NCBI Official Symbol: | KCNAB1 |
NCBI Official Synonym Symbols: | hKvb3; AKR6A3; KCNA1B; Kvb1.3; hKvBeta3; KV-BETA-1 |
NCBI Protein Information: | voltage-gated potassium channel subunit beta-1 |
UniProt Protein Name: | Voltage-gated potassium channel subunit beta-1 |
UniProt Synonym Protein Names: | K(+) channel subunit beta-1; Kv-beta-1 |
Protein Family: | Voltage-gated potassium channel |
UniProt Gene Name: | KCNAB1 |
UniProt Entry Name: | KCAB1_HUMAN |