KAT2B Antibody (PACO01306)
- SKU:
- PACO01306
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
| 抗体名: | KAT2B Antibody |
| 抗体コード: | PACO01306 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | WB:1:500-1:2000, IHC:1:100-1:300 |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | synthesized peptide derived from the C-terminal region of human PCAF. |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | KAT2B; PCAF; Histone acetyltransferase KAT2B; Histone acetyltransferase PCAF; Histone acetylase PCAF; Lysine acetyltransferase 2B; P300/CBP-associated factor; P/CAF |
| UniProt Protein Function: | PCAF: Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Interacts with SIRT1. Interacts (unsumoylated form) with NR2C1; the interaction promotes transactivation activity. Interacts with EP300, CREBBP and DDX17. Interacts with NCOA1 and NCOA3. Component of a large chromatin remodeling complex, at least composed of MYSM1, KAT2B/PCAF, RBM10 and KIF11/TRIP5. Interacts with NR2C2 (hypophosphorylated and unsumoylated form); the interaction promotes the transactivation activity of NR2C2. Binds to HTLV-1 Tax. Interacts with and acetylates HIV-1 Tat. Interacts with KLF1; the interaction does not acetylate KLF1 and there is no enhancement of its transactivational activity. Interacts with NFE4. Interacts with MECOM. Interacts with E2F1; the interaction acetylates E2F1 augmenting its DNA-binding and transcriptional activity. Ubiquitously expressed but most abundant in heart and skeletal muscle. Belongs to the GCN5 family. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; EC 2.3.1.48; Acetyltransferase Chromosomal Location of Human Ortholog: 3p24 Cellular Component: nucleoplasm; nucleus Molecular Function:acetyltransferase activity; chromatin binding; cyclin-dependent protein kinase inhibitor activity; histone acetyltransferase activity; histone deacetylase binding; lysine N-acetyltransferase activity; protein binding; protein complex binding; protein kinase binding; transcription coactivator activity; transcription cofactor activity; transcription factor binding Biological Process: cell cycle arrest; cellular response to insulin stimulus; chromatin remodeling; internal peptidyl-lysine acetylation; N-terminal peptidyl-lysine acetylation; negative regulation of cell proliferation; Notch signaling pathway; peptidyl-lysine acetylation; positive regulation of gene expression, epigenetic; positive regulation of transcription from RNA polymerase II promoter; protein amino acid acetylation; transcription initiation from RNA polymerase II promoter |
| NCBI Summary: | CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q92831 |
| NCBI GenInfo Identifier: | 83287776 |
| NCBI Gene ID: | 8850 |
| NCBI Accession: | Q92831.3 |
| UniProt Secondary Accession: | Q92831,Q6NSK1, |
| UniProt Related Accession: | Q92831 |
| Molecular Weight: | 93,013 Da |
| NCBI Full Name: | Histone acetyltransferase KAT2B |
| NCBI Synonym Full Names: | lysine acetyltransferase 2B |
| NCBI Official Symbol: | KAT2B |
| NCBI Official Synonym Symbols: | CAF; PCAF; P/CAF |
| NCBI Protein Information: | histone acetyltransferase KAT2B |
| UniProt Protein Name: | Histone acetyltransferase KAT2B |
| UniProt Synonym Protein Names: | Histone acetyltransferase PCAF; Histone acetylase PCAF; Lysine acetyltransferase 2B; P300/CBP-associated factor; P/CAF |
| Protein Family: | Histone acetyltransferase |
| UniProt Gene Name: | KAT2B |
| UniProt Entry Name: | KAT2B_HUMAN |