JMJD1C Antibody, FITC conjugated (PACO46568)
- SKU:
- PACO46568
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | JMJD1C Antibody, FITC conjugated (PACO46568) |
抗体コード: | PACO46568 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Probable JmjC domain-containing histone demethylation protein 2C protein (539-648AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). |
シノニム: | Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8), JMJD1C, JHDM2C KIAA1380 TRIP8 |
UniProt Protein Function: | TRIP8: Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes. Belongs to the JHDM2 histone demethylase family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: EC 1.14.11.-; Demethylase; Oxidoreductase; Nuclear receptor co-regulator; Transcription, coactivator/corepressorChromosomal Location of Human Ortholog: 10q21.3Cellular Component: nucleoplasmMolecular Function: histone demethylase activity (H3-K9 specific); protein binding; thyroid hormone receptor bindingBiological Process: blood coagulation; regulation of transcription, DNA-dependent |
UniProt Protein Details: | |
NCBI Summary: | The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] |
UniProt Code: | Q15652 |
NCBI GenInfo Identifier: | 85541650 |
NCBI Gene ID: | 221037 |
NCBI Accession: | Q15652.2 |
UniProt Secondary Accession: | Q15652,Q5SQZ8, Q5SQZ9, Q5SR00, Q7Z3E7, Q8N3U0, Q96KB9 Q9P2G7, A0T124 |
UniProt Related Accession: | Q15652 |
Molecular Weight: | 263,157 Da |
NCBI Full Name: | Probable JmjC domain-containing histone demethylation protein 2C |
NCBI Synonym Full Names: | jumonji domain containing 1C |
NCBI Official Symbol: | JMJD1C |
NCBI Official Synonym Symbols: | TRIP8; TRIP-8 |
NCBI Protein Information: | probable JmjC domain-containing histone demethylation protein 2C |
UniProt Protein Name: | Probable JmjC domain-containing histone demethylation protein 2C |
UniProt Synonym Protein Names: | Jumonji domain-containing protein 1C; Thyroid receptor-interacting protein 8; TR-interacting protein 8; TRIP-8 |
Protein Family: | Probable JmjC domain-containing histone demethylation protein |
UniProt Gene Name: | JMJD1C |
UniProt Entry Name: | JHD2C_HUMAN |