ITM2B Antibody, HRP conjugated (PACO55571)
- SKU:
- PACO55571
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | ITM2B Antibody, HRP conjugated (PACO55571) |
抗体コード: | PACO55571 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Integral membrane protein 2B protein (81-148AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Plays a regulatory role in the processing of the beta-amyloid A4 precursor protein (APP) and acts as an inhibitor of the beta-amyloid peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites. |
シノニム: | Integral membrane protein 2B (Immature BRI2) (imBRI2) (Protein E25B) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form (Mature BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)], ITM2B, BRI BRI2 |
UniProt Protein Function: | ITM2B: Plays a regulatory role in the processing of the beta- amyloid A4 precursor protein (APP) and acts as an inhibitor of the beta-amyloid peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites. Defects in ITM2B are a cause of cerebral amyloid angiopathy ITM2B-related type 1 (CAA-ITM2B1). A disorder characterized by amyloid deposition in the walls of cerebral blood vessels and neurodegeneration in the central nervous system. Cerebral amyloid angiopathy, non-neuritic and perivascular plaques and neurofibrillary tangles are the predominant pathological lesions. Clinical features include progressive mental deterioration, spasticity and muscular rigidity. ABri amyloidogenic peptide variant is cleaved at the normal furin processing site to generate peptide that accumulates in the brain and produces amyloid fibrils responsible for neuronal dysfunction and dementia. ABri peptide variant forms fibrila in vitro. Defects in ITM2B are a cause of cerebral amyloid angiopathy ITM2B-related type 2 (CAA-ITM2B2); also known as heredopathia ophthalmo-oto-encephalica. A disorder characterized by amyloid deposition in the walls of the blood vessels of the cerebrum, choroid plexus, cerebellum, spinal cord and retina. Plaques and neurofibrillary tangles are observed in the hippocampus. Clinical features include progressive ataxia, dementia, cataracts and deafness. ADan amyloidogenic peptide variant is cleaved at the normal furin processing site to generate peptide that accumulates in the brain and produces amyloid fibrils responsible for neuronal dysfunction and dementia. Belongs to the ITM2 family. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 13q14.3 Cellular Component: extracellular region; extracellular space; Golgi apparatus; intracellular membrane-bound organelle; membrane; plasma membrane Molecular Function:beta-amyloid binding; protein binding Biological Process: cellular protein metabolic process; negative regulation of amyloid precursor protein biosynthetic process; nervous system development Disease: Cerebral Amyloid Angiopathy, Itm2b-related, 1; Cerebral Amyloid Angiopathy, Itm2b-related, 2; Retinal Dystrophy With Inner Retinal Dysfunction And Ganglion Cell Abnormalities |
NCBI Summary: | Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq, Oct 2009] |
UniProt Code: | Q9Y287 |
NCBI GenInfo Identifier: | 12643343 |
NCBI Gene ID: | 9445 |
NCBI Accession: | Q9Y287.1 |
UniProt Secondary Accession: | Q9Y287,Q5W0A3, Q96B24, Q9NYH1, |
UniProt Related Accession: | Q9Y287 |
Molecular Weight: | 18,283 Da |
NCBI Full Name: | Integral membrane protein 2B |
NCBI Synonym Full Names: | integral membrane protein 2B |
NCBI Official Symbol: | ITM2B |
NCBI Official Synonym Symbols: | BRI; FBD; ABRI; BRI2; E25B; E3-16; RDGCA; imBRI2; BRICD2B |
NCBI Protein Information: | integral membrane protein 2B |
UniProt Protein Name: | Integral membrane protein 2B |
UniProt Synonym Protein Names: | Immature BRI2; imBRI2 |
Protein Family: | Integral membrane protein |
UniProt Gene Name: | ITM2B |
UniProt Entry Name: | ITM2B_HUMAN |