ITGB3 (Ab-773) Antibody (PACO22903)
- SKU:
- PACO22903
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | ITGB3 (Ab-773) Antibody (PACO22903) |
抗体コード: | PACO22903 |
サイズ: | 100ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:1000, IHC:1:50-1:200 |
反応性: | Human, Mouse |
免疫原: | Peptide sequence around aa. 771~775 (P-L-Y-K-E) derived from Human Integrin b3. |
憲法: | Liquid |
ストレージバッファ: | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
精製方法: | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from HL60 and HT29 cells using Integrin b3(Ab-773) Antibody. | |
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Integrin b3(Ab-773) Antibody(left) or the same antibody preincubated with blocking peptide(right). |
バックグラウンド: | Integrin a-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin a-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins a-IIb/beta-3 and a-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin a-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin a-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. |
シノニム: | Platelet membrane glycoprotein IIIa |
UniProt Protein Function: | ITGB3: integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIB/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion Chromosomal Location of Human Ortholog: 17q21.32 Cellular Component: cell surface; filopodium membrane; focal adhesion; integral to plasma membrane; integrin complex; melanosome; microvillus membrane; nucleus; plasma membrane; platelet alpha granule membrane; receptor complex Molecular Function:C-X3-C chemokine binding; cell adhesion molecule binding; coreceptor activity; enzyme binding; extracellular matrix binding; fibroblast growth factor binding; fibronectin binding; identical protein binding; insulin-like growth factor I binding; platelet-derived growth factor receptor binding; protease binding; protein binding; protein disulfide isomerase activity; vascular endothelial growth factor receptor 2 binding Biological Process: activation of protein kinase activity; angiogenesis involved in wound healing; blood coagulation; cell adhesion; cell growth; cell migration; cell-matrix adhesion; cell-substrate adhesion; entry of virus into host cell; extracellular matrix organization and biogenesis; heterotypic cell-cell adhesion; integrin-mediated signaling pathway; leukocyte migration; mesodermal cell differentiation; negative chemotaxis; negative regulation of lipid transport; negative regulation of lipoprotein metabolic process; negative regulation of low-density lipoprotein receptor biosynthetic process; platelet activation; platelet degranulation; positive regulation of endothelial cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein amino acid phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; regulation of bone resorption; smooth muscle cell migration; tube development; vascular endothelial growth factor receptor signaling pathway; wound healing Disease: Bleeding Disorder, Platelet-type, 16; Glanzmann Thrombasthenia; Myocardial Infarction, Susceptibility To |
NCBI Summary: | The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008] |
UniProt Code: | P05106 |
NCBI GenInfo Identifier: | 125987835 |
NCBI Gene ID: | 3690 |
NCBI Accession: | P05106.2 |
UniProt Secondary Accession: | P05106,O15495, Q12806, Q13413, Q14648, Q16499, A0PJW2 D3DXJ8, |
UniProt Related Accession: | P05106 |
Molecular Weight: | 86,694 Da |
NCBI Full Name: | Integrin beta-3 |
NCBI Synonym Full Names: | integrin subunit beta 3 |
NCBI Official Symbol: | ITGB3 |
NCBI Official Synonym Symbols: | GT; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16 |
NCBI Protein Information: | integrin beta-3 |
UniProt Protein Name: | Integrin beta-3 |
UniProt Synonym Protein Names: | Platelet membrane glycoprotein IIIa; GPIIIa; CD_antigen: CD61 |
Protein Family: | Integrin |
UniProt Gene Name: | ITGB3 |
UniProt Entry Name: | ITB3_HUMAN |
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