ITGA3 Antibody, Biotin conjugated (PACO55565)
- SKU:
- PACO55565
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | ITGA3 Antibody, Biotin conjugated (PACO55565) |
抗体コード: | PACO55565 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Integrin alpha-3 protein (168-276AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. |
シノニム: | Integrin alpha-3 (CD49 antigen-like family member C) (FRP-2) (Galactoprotein B3) (GAPB3) (VLA-3 subunit alpha) (CD antigen CD49c) [Cleaved into: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain], ITGA3, MSK18 |
UniProt Protein Function: | Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. |
NCBI Summary: | The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015] |
UniProt Code: | P26006 |
NCBI GenInfo Identifier: | 347595830 |
NCBI Gene ID: | 3675 |
NCBI Accession: | P26006.5 |
UniProt Secondary Accession: | P26006,A7E246, B7ZM80, B9EGQ1, D3DTX4, D3DTX5, |
UniProt Related Accession: | P26006 |
Molecular Weight: | |
NCBI Full Name: | Integrin alpha-3 |
NCBI Synonym Full Names: | integrin subunit alpha 3 |
NCBI Official Symbol: | ITGA3 |
NCBI Official Synonym Symbols: | VL3A; CD49C; FRP-2; GAPB3; ILNEB; MSK18; VCA-2; VLA3a; GAP-B3 |
NCBI Protein Information: | integrin alpha-3 |
UniProt Protein Name: | Integrin alpha-3 |
UniProt Synonym Protein Names: | CD49 antigen-like family member C; FRP-2; Galactoprotein B3; GAPB3 |
Protein Family: | Integrin |
UniProt Gene Name: | ITGA3 |
UniProt Entry Name: | ITA3_HUMAN |