ITGA1 Antibody (PACO54830)
- SKU:
- PACO54830
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | ITGA1 Antibody (PACO54830) |
抗体コード: | PACO54830 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:200-1:500 |
反応性: | Human |
免疫原: | Recombinant Human Integrin alpha-1 protein (242-524AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human liver cancer using PACO54830 at dilution of 1:100. | |
Immunofluorescence staining of HepG2 cells with PACO54830 at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. |
シノニム: | Integrin alpha-1 (CD49 antigen-like family member A) (Laminin and collagen receptor) (VLA-1) (CD antigen CD49a), ITGA1 |
UniProt Protein Function: | ITGA1: Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Belongs to the integrin alpha chain family. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 5q11.2 Cellular Component: neuron projection; focal adhesion; cell surface; membrane; plasma membrane; acrosome; perikaryon; integrin complex; lipid raft; external side of plasma membrane Molecular Function:collagen binding; protein binding; metal ion binding; protein phosphatase binding; receptor binding Biological Process: positive regulation of phosphoprotein phosphatase activity; integrin-mediated signaling pathway; negative regulation of epidermal growth factor receptor signaling pathway; axon guidance; neutrophil chemotaxis; extracellular matrix organization and biogenesis; activation of MAPK activity; cell-matrix adhesion; vasodilation; negative regulation of cell proliferation; muscle contraction; cellular extravasation; positive regulation of neuron apoptosis; blood coagulation |
NCBI Summary: | This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq, Jul 2008] |
UniProt Code: | P56199 |
NCBI GenInfo Identifier: | 124056463 |
NCBI Gene ID: | 3672 |
NCBI Accession: | P56199.2 |
UniProt Secondary Accession: | P56199,B2RNU0, |
UniProt Related Accession: | P56199 |
Molecular Weight: | 130,848 Da |
NCBI Full Name: | Integrin alpha-1 |
NCBI Synonym Full Names: | integrin, alpha 1 |
NCBI Official Symbol: | ITGA1 |
NCBI Official Synonym Symbols: | VLA1; CD49a |
NCBI Protein Information: | integrin alpha-1; VLA-1; laminin and collagen receptor; very late activation protein 1; CD49 antigen-like family member A |
UniProt Protein Name: | Integrin alpha-1 |
UniProt Synonym Protein Names: | CD49 antigen-like family member A; Laminin and collagen receptor; VLA-1; CD_antigen: CD49a |
Protein Family: | Integrin |
UniProt Gene Name: | ITGA1 |
UniProt Entry Name: | ITA1_HUMAN |
Antibodies | ELISA Kits |
Anti-ITGA1 Antibody (CAB16054) | Human ITGA1/CD49a(Integrin alpha-1) ELISA Kit |
ITGA1 Antibody (PACO07342) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |