IRX3 Antibody, Biotin conjugated (PACO55561)
- SKU:
- PACO55561
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | IRX3 Antibody, Biotin conjugated (PACO55561) |
抗体コード: | PACO55561 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Iroquois-class homeodomain protein IRX-3 protein (285-378AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells (By similarity). |
シノニム: | Iroquois-class homeodomain protein IRX-3 (Homeodomain protein IRXB1) (Iroquois homeobox protein 3), IRX3, IRXB1 |
UniProt Protein Function: | IRX3: Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Belongs to the TALE/IRO homeobox family. |
UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 16q12.2 |
NCBI Summary: | IRX3 is a member of the Iroquois homeobox gene family (see IRX1; MIM 606197) and plays a role in an early step of neural development (Bellefroid et al., 1998 [PubMed 9427753]). Members of this family appear to play multiple roles during pattern formation of vertebrate embryos (Lewis et al., 1999 [PubMed 10370142]).[supplied by OMIM, Aug 2009] |
UniProt Code: | P78415 |
NCBI GenInfo Identifier: | 47117874 |
NCBI Gene ID: | 79191 |
NCBI Accession: | P78415.3 |
UniProt Secondary Accession: | P78415,Q7Z4A4, Q7Z4A5, Q8IVC6, |
UniProt Related Accession: | P78415 |
Molecular Weight: | 52,119 Da |
NCBI Full Name: | Iroquois-class homeodomain protein IRX-3 |
NCBI Synonym Full Names: | iroquois homeobox 3 |
NCBI Official Symbol: | IRX3 |
NCBI Official Synonym Symbols: | IRX-1; IRXB1 |
NCBI Protein Information: | iroquois-class homeodomain protein IRX-3 |
UniProt Protein Name: | Iroquois-class homeodomain protein IRX-3 |
UniProt Synonym Protein Names: | Homeodomain protein IRXB1; Iroquois homeobox protein 3 |
Protein Family: | Iroquois-class homeodomain protein |
UniProt Gene Name: | IRX3 |
UniProt Entry Name: | IRX3_HUMAN |