IRS2 Antibody (PACO51662)
- SKU:
- PACO51662
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | IRS2 Antibody (PACO51662) |
抗体コード: | PACO51662 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Insulin receptor substrate 2 protein (766-1001AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO51662 at dilution of 1:100. |
![]() | Immunofluorescent analysis of Hela cells using PACO51662 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
![]() | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO51662 at dilution of 1:100. |
バックグラウンド: | May mediate the control of various cellular processes by insulin. |
シノニム: | Insulin receptor substrate 2 (IRS-2), IRS2 |
UniProt Protein Function: | IRS2: May mediate the control of various cellular processes by insulin. Interacts with PHIP. |
UniProt Protein Details: | Protein type:Adaptor/scaffold; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 13q34 Cellular Component: cytosol; plasma membrane Molecular Function:1-phosphatidylinositol-3-kinase activity; insulin receptor binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphoinositide 3-kinase binding; protein binding; Ras guanyl-nucleotide exchange factor activity Biological Process: cellular response to insulin stimulus; glucose metabolic process; insulin receptor signaling pathway; lipid homeostasis; MAPKKK cascade; negative regulation of B cell apoptosis; negative regulation of kinase activity; phosphoinositide-mediated signaling; positive regulation of B cell proliferation; positive regulation of fatty acid beta-oxidation; positive regulation of glucose import; positive regulation of glycogen biosynthetic process; positive regulation of insulin secretion; regulation of lipid metabolic process; regulation of phosphoinositide 3-kinase cascade; response to glucose stimulus; signal transduction Disease: Diabetes Mellitus, Noninsulin-dependent |
NCBI Summary: | This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9Y4H2 |
NCBI GenInfo Identifier: | 62298062 |
NCBI Gene ID: | 8660 |
NCBI Accession: | Q9Y4H2.2 |
UniProt Secondary Accession: | Q9Y4H2,Q96RR2, Q9BZG0, Q9Y6I5, |
UniProt Related Accession: | Q9Y4H2 |
Molecular Weight: | 137,334 Da |
NCBI Full Name: | Insulin receptor substrate 2 |
NCBI Synonym Full Names: | insulin receptor substrate 2 |
NCBI Official Symbol: | IRS2 |
NCBI Official Synonym Symbols: | IRS-2 |
NCBI Protein Information: | insulin receptor substrate 2 |
UniProt Protein Name: | Insulin receptor substrate 2 |
Protein Family: | Insulin receptor substrate |
UniProt Gene Name: | IRS2 |
UniProt Entry Name: | IRS2_HUMAN |
Antibodies | ELISA Kits |
Anti-IRS2 Antibody (CAB7945) | Human IRS2 / Insulin receptor substrate 2 ELISA Kit |
IRS2 Antibody (PACO07297) | Human Insulin receptor substrate 2 (IRS2) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-HRP-conjugated Beta Actin Antibody (CABC028) |