IRGM Antibody (PACO43906)
- SKU:
- PACO43906
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | IRGM Antibody (PACO43906) |
抗体コード: | PACO43906 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Immunity-related GTPase family M protein (1-181AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
バックグラウンド: | Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility. |
シノニム: | Immunity-related GTPase family M protein (EC 3.6.5.-) (Immunity-related GTPase family M protein 1) (Interferon-inducible protein 1) (LPS-stimulated RAW 264.7 macrophage protein 47 homolog) (LRG-47), IRGM, IFI1 IRGM1 LRG47 |
UniProt Protein Function: | IRGM: Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility. Defects in IRGM are the cause of susceptibility to inflammatory bowel disease type 19 (IBD19). A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Belongs to the interferon-inducible GTPase family. |
UniProt Protein Details: | Protein type:Endoplasmic reticulum; EC 3.6.5.-; Hydrolase Chromosomal Location of Human Ortholog: 5q33.1 Disease: Inflammatory Bowel Disease 19; Mycobacterium Tuberculosis, Susceptibility To |
NCBI Summary: | This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis.[provided by RefSeq, Oct 2010] |
UniProt Code: | A1A4Y4 |
NCBI GenInfo Identifier: | 171473037 |
NCBI Gene ID: | 345611 |
NCBI Accession: | A1A4Y4.2 |
UniProt Secondary Accession: | A1A4Y4,B3VEX0, |
UniProt Related Accession: | A1A4Y4 |
Molecular Weight: | 20,142 Da |
NCBI Full Name: | Immunity-related GTPase family M protein |
NCBI Synonym Full Names: | immunity related GTPase M |
NCBI Official Symbol: | IRGM |
NCBI Official Synonym Symbols: | IFI1; IRGM1; LRG47; LRG-47 |
NCBI Protein Information: | immunity-related GTPase family M protein |
UniProt Protein Name: | Immunity-related GTPase family M protein |
UniProt Synonym Protein Names: | Immunity-related GTPase family M protein 1; Interferon-inducible protein 1; LPS-stimulated RAW 264.7 macrophage protein 47 homolog; LRG-47 |
Protein Family: | Immunity-related GTPase family M protein |
UniProt Gene Name: | IRGM |
UniProt Entry Name: | IRGM_HUMAN |