IRF5 Antibody (PACO45946)
- SKU:
- PACO45946
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | IRF5 Antibody (PACO45946) |
抗体コード: | PACO45946 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human, Mouse |
免疫原: | Recombinant Human Interferon regulatory factor 5 protein (214-395AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: A549 whole cell lysate, Hela whole cell lysate, NIH/3T3 whole cell lysate, SH-SY5Y whole cell lysate. All lanes: IRF5 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 57, 58, 55, 48, 18 kDa. Observed band size: 57 kDa.. | |
Immunofluorescent analysis of Hela cells using PACO45946 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO45946 at dilution of 1:100. |
バックグラウンド: | Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling. |
シノニム: | Interferon regulatory factor 5 (IRF-5), IRF5 |
UniProt Protein Function: | IRF5: Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling. Homodimer, when phosphorylated. Belongs to the IRF family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 7q32 Cellular Component: cytoplasm; cytosol; nucleus Molecular Function:protein binding; transcription factor activity Biological Process: transcription, DNA-dependent; positive regulation of apoptosis; response to muramyl dipeptide; positive regulation of interleukin-12 production; cytokine and chemokine mediated signaling pathway; response to peptidoglycan; positive regulation of interferon-beta production; positive regulation of transcription from RNA polymerase II promoter; defense response to virus; positive regulation of interferon-alpha production Disease: Systemic Lupus Erythematosus, Susceptibility To, 10; Inflammatory Bowel Disease 14 |
NCBI Summary: | This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Multiple transcript variants encoding different isoforms have been found for this gene, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Mar 2010] |
UniProt Code: | Q13568 |
NCBI GenInfo Identifier: | 20178305 |
NCBI Gene ID: | 3663 |
NCBI Accession: | Q13568.2 |
UniProt Secondary Accession: | Q13568,Q1A7B4, Q64GA9, Q64GB1, Q64GB2, Q6RCM8, Q9BQF0 A4D1J8, A8DUA8, A8DUA9, E7EQ16, E7EW54, |
UniProt Related Accession: | Q13568 |
Molecular Weight: | 498 |
NCBI Full Name: | Interferon regulatory factor 5 |
NCBI Synonym Full Names: | interferon regulatory factor 5 |
NCBI Official Symbol: | IRF5 |
NCBI Official Synonym Symbols: | SLEB10 |
NCBI Protein Information: | interferon regulatory factor 5 |
UniProt Protein Name: | Interferon regulatory factor 5 |
Protein Family: | Interferon regulatory factor |
UniProt Gene Name: | IRF5 |
UniProt Entry Name: | IRF5_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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