IRAK2 Antibody (PACO06591)
- SKU:
- PACO06591
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | IRAK2 Antibody (PACO06591) |
抗体コード: | PACO06591 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:40000, WB:1:500-1:2000 |
反応性: | Human |
免疫原: | Synthesized peptide derived from the Internal region of human IRAK-2. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot analysis of Jurkat HuvEc cells using IRAK-2 Polyclonal Antibody. |
![]() | Western Blot analysis of 293 cells using IRAK-2 Polyclonal Antibody. |
シノニム: | IRAK2; Interleukin-1 receptor-associated kinase-like 2; IRAK-2 |
UniProt Protein Function: | IRAK2: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. |
UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; Kinase, protein; TKL group; IRAK family Chromosomal Location of Human Ortholog: 3p25.3 Cellular Component: cytoplasm; cytosol; endosome membrane; nucleus; plasma membrane Molecular Function:protein binding; protein heterodimerization activity; protein homodimerization activity; protein serine/threonine kinase activity Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; I-kappaB kinase/NF-kappaB cascade; inflammatory response; inhibition of NF-kappaB transcription factor; JNK cascade; MyD88-dependent toll-like receptor signaling pathway; protein amino acid phosphorylation; regulation of cytokine and chemokine mediated signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway |
NCBI Summary: | IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008] |
UniProt Code: | O43187 |
NCBI GenInfo Identifier: | 125987833 |
NCBI Gene ID: | 3656 |
NCBI Accession: | O43187.2 |
UniProt Secondary Accession: | O43187,Q08AG6, Q5K546, B4DQZ6, |
UniProt Related Accession: | O43187 |
Molecular Weight: | 69,433 Da |
NCBI Full Name: | Interleukin-1 receptor-associated kinase-like 2 |
NCBI Synonym Full Names: | interleukin 1 receptor associated kinase 2 |
NCBI Official Symbol: | IRAK2 |
NCBI Official Synonym Symbols: | IRAK-2 |
NCBI Protein Information: | interleukin-1 receptor-associated kinase-like 2 |
UniProt Protein Name: | Interleukin-1 receptor-associated kinase-like 2 |
Protein Family: | Interleukin-1 receptor-associated kinase |
UniProt Gene Name: | IRAK2 |
UniProt Entry Name: | IRAK2_HUMAN |