IQGAP3 Antibody (PACO14592)
- SKU:
- PACO14592
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | IQGAP3 Antibody (PACO14592) |
抗体コード: | PACO14592 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
反応性: | Human, Mouse |
免疫原: | Fusion protein of human IQGAP3 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse lung tissue, Primary antibody: PACO14592(IQGAP3 Antibody) at dilution 1/850, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
バックグラウンド: | IQGAP3 (IQ motif containing GTPase activating protein 3) is a 1,631 amino acid, protein that acts as an effector of Cdc42 and Rac 1, linking their activation to the cytoskeleton during neuronal morphogenesis. A novel member of the IQGAP family, IQGAP3 is highly expressed in brain where it localizes to axons of hippocampal neurons. IQGAP3 contains one Ras-GAP domain, a CH (calponin-homology) domain, four IQ domains and is encoded by a gene located on human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma. |
シノニム: | IQ motif containing GTPase activating protein 3 |
UniProt Protein Function: | IQGAP3: |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; GAPs, Ras; GAPs Chromosomal Location of Human Ortholog: 1q21.3 Cellular Component: cytosol; intercellular junction; lateral plasma membrane Molecular Function:calmodulin binding; GTPase activator activity; Rho GTPase binding Biological Process: activation of MAPK activity; G1/S transition of mitotic cell cycle; positive regulation of GTPase activity; positive regulation of mammary gland epithelial cell proliferation; Ras protein signal transduction; regulation of cell size; small GTPase mediated signal transduction |
UniProt Code: | Q86VI3 |
NCBI GenInfo Identifier: | 229462887 |
NCBI Gene ID: | 128239 |
NCBI Accession: | Q86VI3.2 |
UniProt Secondary Accession: | Q86VI3,Q5T3H8, |
UniProt Related Accession: | Q86VI3 |
Molecular Weight: | 184,699 Da |
NCBI Full Name: | Ras GTPase-activating-like protein IQGAP3 |
NCBI Synonym Full Names: | IQ motif containing GTPase activating protein 3 |
NCBI Official Symbol: | IQGAP3 |
NCBI Protein Information: | ras GTPase-activating-like protein IQGAP3 |
UniProt Protein Name: | Ras GTPase-activating-like protein IQGAP3 |
Protein Family: | Ras GTPase-activating-like protein |
UniProt Gene Name: | IQGAP3 |
UniProt Entry Name: | IQGA3_HUMAN |