IPO13 Antibody (PACO16545)
- SKU:
- PACO16545
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | IPO13 Antibody (PACO16545) |
抗体コード: | PACO16545 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
反応性: | Human, Mouse, Rat |
免疫原: | Fusion protein of human IPO13 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16545(IPO13 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200). |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16545(IPO13 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | This gene encodes a member of the importin-β family of nuclear transport proteins. The encoded protein mediates the import of specific cargo proteins from the cytoplasm to the nucleus and is dependent on the Ras-related nuclear protein-GTPase system. The encoded protein is also involved in nuclear export of the eukaryotic translation initiation factor 1A. |
シノニム: | importin 13 |
UniProt Protein Function: | IPO13: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13. Belongs to the importin beta family. |
UniProt Protein Details: | Protein type:Nuclear export; Nuclear import; Karyopherin Chromosomal Location of Human Ortholog: 1p34.1 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding; Ran GTPase binding Biological Process: protein import into nucleus |
UniProt Code: | O94829 |
NCBI GenInfo Identifier: | 50400817 |
NCBI Gene ID: | |
NCBI Accession: | O94829.3 |
Molecular Weight: | Predicted Molecular Mass: 24.9kDaAccurate Molecular Mass: 25kDa |
NCBI Full Name: | Importin-13 |
UniProt Protein Name: | Importin-13 |
UniProt Synonym Protein Names: | Karyopherin-13; Kap13; Ran-binding protein 13; RanBP13 |
Protein Family: | Importin |
UniProt Gene Name: | IPO13 |
UniProt Entry Name: | IPO13_HUMAN |