IPO11 Antibody, FITC conjugated (PACO42072)
- SKU:
- PACO42072
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | IPO11 Antibody, FITC conjugated (PACO42072) |
抗体コード: | PACO42072 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Importin-11 protein (1-270AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity). |
シノニム: | Importin-11 (Imp11) (Ran-binding protein 11) (RanBP11), IPO11, RANBP11 |
UniProt Protein Function: | IPO11: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of UBE2E3, and of RPL12. Belongs to the importin beta family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Nuclear import; Karyopherin Chromosomal Location of Human Ortholog: 5q12.1 Cellular Component: cytosol; nuclear envelope Molecular Function:protein binding; protein transporter activity Biological Process: transcription factor import into nucleus |
NCBI Summary: | Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see KPNB1; 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000 [PubMed 11032817]).[supplied by OMIM, Sep 2008] |
UniProt Code: | Q9UI26 |
NCBI GenInfo Identifier: | 50401199 |
NCBI Gene ID: | 51194 |
NCBI Accession: | Q9UI26.1 |
UniProt Secondary Accession: | Q9UI26,Q8N5R2, Q9NSJ6, Q9NVB1, A6NGJ5, B4DZ73, D3DW98 |
UniProt Related Accession: | Q9UI26 |
Molecular Weight: | 117,008 Da |
NCBI Full Name: | Importin-11 |
NCBI Synonym Full Names: | importin 11 |
NCBI Official Symbol: | IPO11 |
NCBI Official Synonym Symbols: | RanBP11 |
NCBI Protein Information: | importin-11 |
UniProt Protein Name: | Importin-11 |
UniProt Synonym Protein Names: | Ran-binding protein 11; RanBP11 |
Protein Family: | Importin |
UniProt Gene Name: | IPO11 |
UniProt Entry Name: | IPO11_HUMAN |