INSIG1 Antibody, Biotin conjugated (PACO53681)
- SKU:
- PACO53681
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | INSIG1 Antibody, Biotin conjugated (PACO53681) |
抗体コード: | PACO53681 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Insulin-induced gene 1 protein (1-87AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth. |
シノニム: | Insulin-induced gene 1 protein (INSIG-1), INSIG1 |
UniProt Protein Function: | INSIG1: Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth. Belongs to the INSIG family. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 7q36 Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane Molecular Function:protein binding Biological Process: cell proliferation; metabolic process; SREBP-mediated signaling pathway |
NCBI Summary: | Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jun 2009] |
UniProt Code: | O15503 |
NCBI GenInfo Identifier: | 115502405 |
NCBI Gene ID: | 3638 |
NCBI Accession: | O15503.3 |
UniProt Secondary Accession: | O15503,Q53XW8, Q9BUV5, A4D2N1, A8K6L0, |
UniProt Related Accession: | O15503 |
Molecular Weight: | 17,530 Da |
NCBI Full Name: | Insulin-induced gene 1 protein |
NCBI Synonym Full Names: | insulin induced gene 1 |
NCBI Official Symbol: | INSIG1 |
NCBI Official Synonym Symbols: | CL6; CL-6 |
NCBI Protein Information: | insulin-induced gene 1 protein |
UniProt Protein Name: | Insulin-induced gene 1 protein |
Protein Family: | Insulin-induced gene 1 protein |
UniProt Gene Name: | INSIG1 |
UniProt Entry Name: | INSI1_HUMAN |