INPPL1 Antibody (PACO19849)
- SKU:
- PACO19849
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | INPPL1 Antibody (PACO19849) |
抗体コード: | PACO19849 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:50-1:200 |
反応性: | Human, Mouse, Rat |
免疫原: | Synthetic peptide of human INPPL1 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19849(INPPL1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19849(INPPL1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. |
シノニム: | inositol polyphosphate phosphatase-like 1 |
UniProt Protein Function: | SHIP-2: an SH2-containing inositol phosphatase. Recruited to activated receptor complexes including insulin R, PDGFR and Fc-gamma-R. |
UniProt Protein Details: | Protein type:Carbohydrate Metabolism - inositol phosphate; Phosphatase, lipid; Motility/polarity/chemotaxis; EC 3.1.3.86 Chromosomal Location of Human Ortholog: 11q13 Cellular Component: Golgi apparatus; cytoskeleton; lamellipodium; cytoplasm; plasma membrane; cytosol; filopodium Molecular Function:protein binding; hydrolase activity; SH2 domain binding; actin binding; SH3 domain binding Biological Process: inositol phosphate metabolic process; immune system process; actin filament organization; glucose metabolic process; endocytosis; response to insulin stimulus; post-embryonic development; negative regulation of cell proliferation; phospholipid metabolic process; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; cell adhesion; endochondral ossification Disease: Opsismodysplasia |
NCBI Summary: | The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009] |
UniProt Code: | O15357 |
NCBI GenInfo Identifier: | 269849650 |
NCBI Gene ID: | 3636 |
NCBI Accession: | O15357.2 |
UniProt Secondary Accession: | O15357,Q13577, Q13578, B2RTX5, |
UniProt Related Accession: | O15357 |
Molecular Weight: | 113,176 Da |
NCBI Full Name: | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 |
NCBI Synonym Full Names: | inositol polyphosphate phosphatase-like 1 |
NCBI Official Symbol: | INPPL1 |
NCBI Official Synonym Symbols: | OPSMD; SHIP2 |
NCBI Protein Information: | phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; SHIP-2; INPPL-1; 51C protein; protein 51C; SH2 domain-containing inositol 5'-phosphatase 2; SH2 domain-containing inositol-5'-phosphatase 2; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 |
UniProt Protein Name: | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 |
UniProt Synonym Protein Names: | Inositol polyphosphate phosphatase-like protein 1; INPPL-1; Protein 51C; SH2 domain-containing inositol 5'-phosphatase 2; SH2 domain-containing inositol phosphatase 2; SHIP-2 |
UniProt Gene Name: | INPPL1 |
UniProt Entry Name: | SHIP2_HUMAN |