INPP5B Antibody, HRP conjugated (PACO57821)
- SKU:
- PACO57821
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | INPP5B Antibody, HRP conjugated (PACO57821) |
抗体コード: | PACO57821 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Type II inositol 1,4,5-trisphosphate 5-phosphatase protein (78-178AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events. |
シノニム: | Type II inositol 1,4,5-trisphosphate 5-phosphatase (EC 3.1.3.36) (75 kDa inositol polyphosphate-5-phosphatase) (Phosphoinositide 5-phosphatase) (5PTase), INPP5B, OCRL2 |
UniProt Protein Function: | INPP5B: Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events. Belongs to the inositol 1,4,5-trisphosphate 5- phosphatase type II family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.36; Phosphatase (non-protein); Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 1p34 Cellular Component: Golgi apparatus; phagocytic vesicle membrane; membrane; early endosome membrane; cytoplasm; integral to membrane; plasma membrane; ER-Golgi intermediate compartment; cytosol Molecular Function:protein binding; metal ion binding; phosphoinositide 5-phosphatase activity Biological Process: sperm motility; regulation of small GTPase mediated signal transduction; inositol phosphate metabolic process; in utero embryonic development; small GTPase mediated signal transduction; phosphoinositide dephosphorylation; spermatogenesis |
NCBI Summary: | This gene encodes a member of a family of inositol polyphosphate-5-phosphatases. These enzymes function in the regulation of calcium signaling by inactivating inositol phosphates. The encoded protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2014] |
UniProt Code: | P32019 |
NCBI GenInfo Identifier: | 37590185 |
NCBI Gene ID: | 3633 |
NCBI Accession: | BC058932 |
UniProt Secondary Accession: | P32019,Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53 Q86YE1, C9J6U5, |
UniProt Related Accession: | P32019 |
Molecular Weight: | Calculated MW: 113 kDaObserved MW: 75 kDa |
NCBI Full Name: | INPP5B protein |
NCBI Synonym Full Names: | inositol polyphosphate-5-phosphatase, 75kDa |
NCBI Official Symbol: | INPP5B |
NCBI Official Synonym Symbols: | 5PTase |
NCBI Protein Information: | type II inositol 1,4,5-trisphosphate 5-phosphatase; phosphoinositide 5-phosphatase |
UniProt Protein Name: | Type II inositol 1,4,5-trisphosphate 5-phosphatase |
UniProt Synonym Protein Names: | 75 kDa inositol polyphosphate-5-phosphatase; Phosphoinositide 5-phosphatase; 5PTase |
Protein Family: | Type II inositol 1,4,5-trisphosphate 5-phosphatase |
UniProt Gene Name: | INPP5B |
UniProt Entry Name: | I5P2_HUMAN |