INF2 Antibody, HRP conjugated (PACO60049)
- SKU:
- PACO60049
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | INF2 Antibody, HRP conjugated (PACO60049) |
抗体コード: | PACO60049 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Inverted formin-2 protein (926-1047AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Severs actin filaments and accelerates their polymerization and depolymerization. |
シノニム: | Inverted formin-2 (HBEBP2-binding protein C), INF2, C14orf151 C14orf173 |
UniProt Protein Function: | INF2: Severs actin filaments and accelerates their polymerization and depolymerization. Defects in INF2 are the cause of focal segmental glomerulosclerosis type 5 (FSGS5). A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. Defects in INF2 are the cause of Charcot-Marie-Tooth disease, dominant intermediate type E (CMTDIE). A form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. The dominant intermediate type E is characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec. Patients additionally manifest focal segmental glomerulonephritis, proteinuria, progression to end- stage renal disease, and a characteristic histologic pattern on renal biopsy. Belongs to the formin homology family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 14q32.33 Cellular Component: perinuclear region of cytoplasm Disease: Charcot-marie-tooth Disease, Dominant Intermediate E; Focal Segmental Glomerulosclerosis 5 |
NCBI Summary: | This gene represents a member of the formin family of proteins. It is considered a diaphanous formin due to the presence of a diaphanous inhibitory domain located at the N-terminus of the encoded protein. Studies of a similar mouse protein indicate that the protein encoded by this locus may function in polymerization and depolymerization of actin filaments. Mutations at this locus have been associated with focal segmental glomerulosclerosis 5.[provided by RefSeq, Aug 2010] |
UniProt Code: | Q27J81 |
NCBI GenInfo Identifier: | 166215588 |
NCBI Gene ID: | 64423 |
NCBI Accession: | Q27J81.2 |
UniProt Secondary Accession: | Q27J81,Q27J83, Q69YL8, Q6P1X7, Q6PK22, Q86TR7, Q9BRM1 Q9H6N1, |
UniProt Related Accession: | Q27J81 |
Molecular Weight: | 25,954 Da |
NCBI Full Name: | Inverted formin-2 |
NCBI Synonym Full Names: | inverted formin, FH2 and WH2 domain containing |
NCBI Official Symbol: | INF2 |
NCBI Official Synonym Symbols: | FSGS5; CMTDIE; pp9484; C14orf151; C14orf173 |
NCBI Protein Information: | inverted formin-2 |
UniProt Protein Name: | Inverted formin-2 |
UniProt Synonym Protein Names: | HBEBP2-binding protein C |
Protein Family: | Inverted formin |
UniProt Gene Name: | INF2 |
UniProt Entry Name: | INF2_HUMAN |