ILF2 Antibody (PACO24712)
- SKU:
- PACO24712
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | ILF2 Antibody (PACO24712) |
抗体コード: | PACO24712 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Interleukin enhancer-binding factor 2 protein (1-390AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot All lanes: ILF2 antibody at 2µg/ml + 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/15000 dilution Predicted band size: 44 kDa Observed band size: 44 kDa . |
![]() | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO24712 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human liver tissue using PACO24712 at dilution of 1:100. |
バックグラウンド: | EIF3S2 is the largest of the EIFs. It consists of at least 10 nonidentical subunits in mammals. In S. cerevisiae the p39 subunit contains WD repeats; these are thought to mediate protein-protein interactions. The p39 protein appears to be essential for maintaining the integrity of the yeast EIF3 complex. The mammalian EIF3-p36 subunit is homologous to yeast p39. |
シノニム: | Interleukin enhancer-binding factor 2 (Nuclear factor of activated T-cells 45 kDa), ILF2, NF45 |
UniProt Protein Function: | ILF2: Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. |
UniProt Protein Details: | Protein type:RNA-binding; Transcription, coactivator/corepressor; Nucleolus Chromosomal Location of Human Ortholog: 1q21.3 Cellular Component: nucleoplasm; membrane; cytoplasm; nucleolus; ribonucleoprotein complex; nucleus Molecular Function:transferase activity; protein binding; DNA binding; double-stranded RNA binding; ATP binding Biological Process: transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; immune response |
NCBI Summary: | The protein encoded by this gene is a transcription factor required for T-cell expression of the interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. The encoded 45 kDa protein (NF45, ILF2) forms a complex with the 90 kDa interleukin enhancer-binding factor 3 (NF90, ILF3), and this complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm, to repair DNA breaks by nonhomologous end joining, and to negatively regulate the microRNA processing pathway. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. Alternative splicing results in multiple transcript variants. Related pseudogenes have been found on chromosomes 3 and 14. [provided by RefSeq, Dec 2014] |
UniProt Code: | Q12905 |
NCBI GenInfo Identifier: | 62510764 |
NCBI Gene ID: | 3608 |
NCBI Accession: | Q12905.2 |
UniProt Secondary Accession: | Q12905,Q5SR10, Q5SR11, Q7L7R3, Q9BWD4, Q9P1N0, A6NDB0 B2R8G7, |
UniProt Related Accession: | Q12905 |
Molecular Weight: | 390 |
NCBI Full Name: | Interleukin enhancer-binding factor 2 |
NCBI Synonym Full Names: | interleukin enhancer binding factor 2 |
NCBI Official Symbol: | ILF2 |
NCBI Official Synonym Symbols: | NF45; PRO3063 |
NCBI Protein Information: | interleukin enhancer-binding factor 2; interleukin enhancer binding factor 2, 45kD; nuclear factor of activated T-cells, 45-kDa; interleukin enhancer binding factor 2, 45kDa |
UniProt Protein Name: | Interleukin enhancer-binding factor 2 |
UniProt Synonym Protein Names: | Nuclear factor of activated T-cells 45 kDa |
Protein Family: | Interleukin enhancer-binding factor |
UniProt Gene Name: | ILF2 |
UniProt Entry Name: | ILF2_HUMAN |