IL36A Antibody (PACO45087)
- SKU:
- PACO45087
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | IL36A Antibody (PACO45087) |
抗体コード: | PACO45087 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Interleukin-36 α protein (1-158AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO45087 at dilution of 1:100. |
バックグラウンド: | Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by upregulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T-cell proliferation. May play a role in proinflammatory effects in the lung. |
シノニム: | Interleukin-36 α (FIL1 epsilon) (Interleukin-1 epsilon) (IL-1 epsilon) (Interleukin-1 family member 6) (IL-1F6), IL36A, FIL1E IL1E IL1F6 |
UniProt Protein Function: | IL1F6: Belongs to the IL-1 family. |
UniProt Protein Details: | Protein type:Cytokine Chromosomal Location of Human Ortholog: 2q12-q14.1 Cellular Component: extracellular region; extracellular space Molecular Function:cytokine activity; interleukin-1 receptor binding Biological Process: cytokine and chemokine mediated signaling pathway |
NCBI Summary: | The protein encoded by this gene is a cytokine that can activate NF-kappa-B and MAPK signaling pathways to generate an inflammatory response. The encoded protein functions primarily in skin and demonstrates increased expression in psoriasis. In addition, decreased expression of this gene has been linked to a poor prognosis in both hepatocellular carcinoma and colorectal cancer patients. [provided by RefSeq, Nov 2015] |
UniProt Code: | Q9UHA7 |
NCBI GenInfo Identifier: | 25008601 |
NCBI Gene ID: | 27179 |
NCBI Accession: | Q9UHA7.1 |
UniProt Secondary Accession: | Q9UHA7,Q53SR7, Q5BLR4, Q7RTZ8, B2RAD9, |
UniProt Related Accession: | Q9UHA7 |
Molecular Weight: | 17,684 Da |
NCBI Full Name: | Interleukin-36 alpha |
NCBI Synonym Full Names: | interleukin 36, alpha |
NCBI Official Symbol: | IL36A |
NCBI Official Synonym Symbols: | FIL1; FIL1E; IL1F6; IL-1F6; IL1(EPSILON); FIL1(EPSILON) |
NCBI Protein Information: | interleukin-36 alpha |
UniProt Protein Name: | Interleukin-36 alpha |
UniProt Synonym Protein Names: | FIL1 epsilon; Interleukin-1 epsilon; IL-1 epsilon; Interleukin-1 family member 6; IL-1F6 |
Protein Family: | Interleukin |
UniProt Gene Name: | IL36A |
UniProt Entry Name: | IL36A_HUMAN |
Antibodies | ELISA Kits |
Anti-IL36A Antibody (CAB8207) | Human IL-36A / IL-36 alpha ELISA Kit |
Human IL-36A ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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