UniProt Protein Function: | IL2RB: Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation. Interacts with HTLV-1 accessory protein p12I. Belongs to the type I cytokine receptor family. Type 4 subfamily. |
UniProt Protein Details: | Protein type:Receptor, cytokine; Membrane protein, integral Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: external side of plasma membrane; integral to plasma membrane; intracellular; membrane; plasma membrane Molecular Function:interleukin-2 binding; interleukin-2 receptor activity; protein binding Biological Process: activation of MAPKK activity; axon guidance; cytokine and chemokine mediated signaling pathway; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; natural killer cell activation; negative regulation of apoptosis; nerve growth factor receptor signaling pathway; protein complex assembly; Ras protein signal transduction; signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway; viral reproduction |
NCBI Summary: | The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. [provided by RefSeq, Jul 2008] |
UniProt Code: | P14784 |
NCBI GenInfo Identifier: | 124321 |
NCBI Gene ID: | 3560 |
NCBI Accession: | P14784.1 |
UniProt Secondary Accession: | P14784,B2R765, |
UniProt Related Accession: | P14784 |
Molecular Weight: | |
NCBI Full Name: | Interleukin-2 receptor subunit beta |
NCBI Synonym Full Names: | interleukin 2 receptor subunit beta |
NCBI Official Symbol: | IL2RB |
NCBI Official Synonym Symbols: | CD122; IL15RB; P70-75 |
NCBI Protein Information: | interleukin-2 receptor subunit beta |
UniProt Protein Name: | Interleukin-2 receptor subunit beta |
UniProt Synonym Protein Names: | High affinity IL-2 receptor subunit beta; p70-75; p75; CD_antigen: CD122 |
Protein Family: | Interleukin-2 receptor |
UniProt Gene Name: | IL2RB |
UniProt Entry Name: | IL2RB_HUMAN |